Skip to main content
Journal cover image

Tumor-associated antigen-based personalized dendritic cell vaccine in solid tumor patients.

Publication ,  Journal Article
Wang, Q-T; Nie, Y; Sun, S-N; Lin, T; Han, R-J; Jiang, J; Li, Z; Li, J-Q; Xiao, Y-P; Fan, Y-Y; Yuan, X-H; Zhang, H; Zhao, B-B; Zeng, M ...
Published in: Cancer Immunol Immunother
July 2020

Tumor-associated antigens (TAAs) have been tested in various clinical trials in cancer treatment but the patterns of specific T cell response to personalized TAA immunization remains to be fully understood. We report antigen-specific T cell responses in patients immunized with dendritic cell vaccines pulsed with personalized TAA panels. Tumor samples from patients were first analyzed to identify overexpressed TAAs. Autologous DCs were then transfected with pre-manufactured mRNAs encoding the full-length TAAs, overexpressed in the patients' tumors. Patients with glioblastoma multiforme (GBM) or advanced lung cancer received DC vaccines transfected with personalized TAA panels, in combination with low-dose cyclophosphamide, poly I:C, imiquimod and anti-PD-1 antibody. Antigen-specific T cell responses were measured. Safety and efficacy were evaluated. A total of ten patients were treated with DC vaccines transfected with personalized TAA panels containing 3-13 different TAAs. Among the seven patients tested for anti-TAA T cell responses, most of the TAAs induced antigen-specific CD4+ and/or CD8+ T cell responses, regardless of their expression levels in the tumor tissues. No Grade III/IV adverse events were observed among these patients. Furthermore, the treated patients were associated with favorable overall survival when compared to patients who received standard treatment in the same institution. Personalized TAA immunization-induced-specific CD4+ and CD8+ T cell responses without obvious autoimmune adverse events and was associated with favorable overall survival. These results support further studies on DC immunization with personalized TAA panels for combined immunotherapeutic regimens in solid tumor patients.Trial registration ClinicalTrials.gov, NCT02709616 (March, 2016), NCT02808364 (June 2016), NCT02808416 (June, 2016).

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cancer Immunol Immunother

DOI

EISSN

1432-0851

Publication Date

July 2020

Volume

69

Issue

7

Start / End Page

1375 / 1387

Location

Germany

Related Subject Headings

  • Survival Rate
  • Prognosis
  • Precision Medicine
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Immunology
  • Immunization
  • Humans
  • Glioblastoma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, Q.-T., Nie, Y., Sun, S.-N., Lin, T., Han, R.-J., Jiang, J., … He, Y.-W. (2020). Tumor-associated antigen-based personalized dendritic cell vaccine in solid tumor patients. Cancer Immunol Immunother, 69(7), 1375–1387. https://doi.org/10.1007/s00262-020-02496-w
Wang, Qian-Ting, Ying Nie, Sheng-Nan Sun, Tao Lin, Ru-Jin Han, Jun Jiang, Zhe Li, et al. “Tumor-associated antigen-based personalized dendritic cell vaccine in solid tumor patients.Cancer Immunol Immunother 69, no. 7 (July 2020): 1375–87. https://doi.org/10.1007/s00262-020-02496-w.
Wang Q-T, Nie Y, Sun S-N, Lin T, Han R-J, Jiang J, et al. Tumor-associated antigen-based personalized dendritic cell vaccine in solid tumor patients. Cancer Immunol Immunother. 2020 Jul;69(7):1375–87.
Wang, Qian-Ting, et al. “Tumor-associated antigen-based personalized dendritic cell vaccine in solid tumor patients.Cancer Immunol Immunother, vol. 69, no. 7, July 2020, pp. 1375–87. Pubmed, doi:10.1007/s00262-020-02496-w.
Wang Q-T, Nie Y, Sun S-N, Lin T, Han R-J, Jiang J, Li Z, Li J-Q, Xiao Y-P, Fan Y-Y, Yuan X-H, Zhang H, Zhao B-B, Zeng M, Li S-Y, Liao H-X, Zhang J, He Y-W. Tumor-associated antigen-based personalized dendritic cell vaccine in solid tumor patients. Cancer Immunol Immunother. 2020 Jul;69(7):1375–1387.
Journal cover image

Published In

Cancer Immunol Immunother

DOI

EISSN

1432-0851

Publication Date

July 2020

Volume

69

Issue

7

Start / End Page

1375 / 1387

Location

Germany

Related Subject Headings

  • Survival Rate
  • Prognosis
  • Precision Medicine
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Immunology
  • Immunization
  • Humans
  • Glioblastoma