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Radiation and Second Primary Thyroid Cancer Following Index Head and Neck Cancer.

Publication ,  Journal Article
Polednik, KM; Simpson, MC; Adjei Boakye, E; Mohammed, KA; J Dombrowski, J; Varvares, MA; Osazuwa-Peters, N
Published in: Laryngoscope
April 2019

OBJECTIVES/HYPOTHESIS: Radiation is thought to increase risk of developing second primary thyroid cancer (SPTC). This study estimated the rate of SPTC following index head and neck cancer (HNC) and determined whether radiation treatment among HNC survivors increased SPTC risk. STUDY DESIGN: Retrospective data analysis. METHOD: The Surveillance, Epidemiology, and End Results database (1975-2014) was queried for cases of index HNC (N = 127,563) that developed SPTC. Adjusted multivariable competing risk proportional hazards model tested risk of developing a SPTC following index HNC. Sensitivity analyses using proportional hazards models were also performed restricting data to patients who 1) received both radiation and chemotherapy and 2) radiation alone. RESULTS: Only 0.2% of index HNC survivors (n = 229) developed SPTC, yielding a rate of 26.1 per 100,000 person-years. For every increasing year of age at diagnosis, patients were 3% less likely to develop an SPTC (adjusted hazard ratio [aHR] = 0.97, 95% CI: 0.96-0.98). Males were also less likely to develop an SPTC (aHR = 0.73, 95% CI: 0.55-0.96). Radiation (aHR = 0.92, 95% CI: 0.68-1.25), surgery (aHR = 0.79, 95% CI: 0.56-1.11), and chemotherapy (aHR = 1.13, 95% CI: 0.76-1.69) were not significantly associated with developing SPTC. The sensitivity models also did not find an association between treatment and risk of SPTC. CONCLUSIONS: Rate of developing SPTC following index HNC was very low, and previous exposure to radiation did not significantly increase risk in our study population. More studies are needed to understand the increasing incidence of thyroid cancer across the United States. LEVEL OF EVIDENCE: NA Laryngoscope, 129:1014-1020, 2019.

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Published In

Laryngoscope

DOI

EISSN

1531-4995

Publication Date

April 2019

Volume

129

Issue

4

Start / End Page

1014 / 1020

Location

United States

Related Subject Headings

  • Thyroid Neoplasms
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Otorhinolaryngology
  • Neoplasms, Second Primary
  • Neoplasms, Radiation-Induced
  • Middle Aged
  • Male
  • Humans
 

Citation

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Polednik, K. M., Simpson, M. C., Adjei Boakye, E., Mohammed, K. A., J Dombrowski, J., Varvares, M. A., & Osazuwa-Peters, N. (2019). Radiation and Second Primary Thyroid Cancer Following Index Head and Neck Cancer. Laryngoscope, 129(4), 1014–1020. https://doi.org/10.1002/lary.27467
Polednik, Katherine M., Matthew C. Simpson, Eric Adjei Boakye, Kahee A. Mohammed, John J Dombrowski, Mark A. Varvares, and Nosayaba Osazuwa-Peters. “Radiation and Second Primary Thyroid Cancer Following Index Head and Neck Cancer.Laryngoscope 129, no. 4 (April 2019): 1014–20. https://doi.org/10.1002/lary.27467.
Polednik KM, Simpson MC, Adjei Boakye E, Mohammed KA, J Dombrowski J, Varvares MA, et al. Radiation and Second Primary Thyroid Cancer Following Index Head and Neck Cancer. Laryngoscope. 2019 Apr;129(4):1014–20.
Polednik, Katherine M., et al. “Radiation and Second Primary Thyroid Cancer Following Index Head and Neck Cancer.Laryngoscope, vol. 129, no. 4, Apr. 2019, pp. 1014–20. Pubmed, doi:10.1002/lary.27467.
Polednik KM, Simpson MC, Adjei Boakye E, Mohammed KA, J Dombrowski J, Varvares MA, Osazuwa-Peters N. Radiation and Second Primary Thyroid Cancer Following Index Head and Neck Cancer. Laryngoscope. 2019 Apr;129(4):1014–1020.
Journal cover image

Published In

Laryngoscope

DOI

EISSN

1531-4995

Publication Date

April 2019

Volume

129

Issue

4

Start / End Page

1014 / 1020

Location

United States

Related Subject Headings

  • Thyroid Neoplasms
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Otorhinolaryngology
  • Neoplasms, Second Primary
  • Neoplasms, Radiation-Induced
  • Middle Aged
  • Male
  • Humans