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Erosive Esophagitis and Symptoms of Gastroesophageal Reflux Disease in Patients with Morbid Obesity with and without Type 2 Diabetes: a Cross-sectional Study.

Publication ,  Journal Article
Lorentzen, J; Medhus, AW; Hertel, JK; Borgeraas, H; Karlsen, T-I; Kolotkin, RL; Sandbu, R; Sifrim, D; Svanevik, M; Hofsø, D; Seip, B; Hjelmesæth, J
Published in: Obes Surg
July 2020

BACKGROUND: Type 2 diabetes (T2DM) is associated with gastroesophageal reflux disease (GERD) in the general population, but the relationship between these conditions in candidates for bariatric surgery is uncertain. We compared the prevalence of GERD and the association between GERD symptoms and esophagitis among bariatric candidates with and without T2DM. METHODS: Cross-sectional study of baseline data from the Oseberg study in Norway. Both groups underwent gastroduodenoscopy and completed validated questionnaires: Gastrointestinal Symptom Rating Scale and Gastroesophageal Reflux Disease Questionnaire. Participants with T2DM underwent 24-h pH-metry. RESULTS: A total of 124 patients with T2DM, 81 women, mean (SD) age 48.6 (9.4) years and BMI 42.3 (5.5) kg/m2, and 64 patients without T2DM, 46 women, age 43.0 (11.0) years and BMI 43.0 (5.0) kg/m2, were included. The proportions of patients reporting GERD-symptoms were low (< 29%) and did not differ significantly between groups, while the proportions of patients with esophagitis were high both in the T2DM and non-T2DM group, 58% versus 47%, p = 0.16. The majority of patients with esophagitis did not have GERD-symptoms (68-80%). Further, 55% of the patients with T2DM had pathologic acid reflux. Among these, 71% also had erosive esophagitis, whereof 67% were asymptomatic. CONCLUSIONS: The prevalence of GERD was similar in bariatric patients with or without T2DM, and the proportion of patients with asymptomatic GERD was high independent of the presence or absence of T2DM. Accordingly, GERD may be underdiagnosed in patients not undergoing a preoperative endoscopy or acid reflux assessment. TRIAL REGISTRATION: Clinical Trials.gov number NCT01778738.

Duke Scholars

Published In

Obes Surg

DOI

EISSN

1708-0428

Publication Date

July 2020

Volume

30

Issue

7

Start / End Page

2667 / 2675

Location

United States

Related Subject Headings

  • Surgery
  • Obesity, Morbid
  • Norway
  • Middle Aged
  • Humans
  • Gastroesophageal Reflux
  • Female
  • Diabetes Mellitus, Type 2
  • Cross-Sectional Studies
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
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Lorentzen, J., Medhus, A. W., Hertel, J. K., Borgeraas, H., Karlsen, T.-I., Kolotkin, R. L., … Hjelmesæth, J. (2020). Erosive Esophagitis and Symptoms of Gastroesophageal Reflux Disease in Patients with Morbid Obesity with and without Type 2 Diabetes: a Cross-sectional Study. Obes Surg, 30(7), 2667–2675. https://doi.org/10.1007/s11695-020-04545-w
Lorentzen, Jolanta, Asle W. Medhus, Jens Kristoffer Hertel, Heidi Borgeraas, Tor-Ivar Karlsen, Ronette L. Kolotkin, Rune Sandbu, et al. “Erosive Esophagitis and Symptoms of Gastroesophageal Reflux Disease in Patients with Morbid Obesity with and without Type 2 Diabetes: a Cross-sectional Study.Obes Surg 30, no. 7 (July 2020): 2667–75. https://doi.org/10.1007/s11695-020-04545-w.
Lorentzen J, Medhus AW, Hertel JK, Borgeraas H, Karlsen T-I, Kolotkin RL, et al. Erosive Esophagitis and Symptoms of Gastroesophageal Reflux Disease in Patients with Morbid Obesity with and without Type 2 Diabetes: a Cross-sectional Study. Obes Surg. 2020 Jul;30(7):2667–75.
Lorentzen, Jolanta, et al. “Erosive Esophagitis and Symptoms of Gastroesophageal Reflux Disease in Patients with Morbid Obesity with and without Type 2 Diabetes: a Cross-sectional Study.Obes Surg, vol. 30, no. 7, July 2020, pp. 2667–75. Pubmed, doi:10.1007/s11695-020-04545-w.
Lorentzen J, Medhus AW, Hertel JK, Borgeraas H, Karlsen T-I, Kolotkin RL, Sandbu R, Sifrim D, Svanevik M, Hofsø D, Seip B, Hjelmesæth J. Erosive Esophagitis and Symptoms of Gastroesophageal Reflux Disease in Patients with Morbid Obesity with and without Type 2 Diabetes: a Cross-sectional Study. Obes Surg. 2020 Jul;30(7):2667–2675.
Journal cover image

Published In

Obes Surg

DOI

EISSN

1708-0428

Publication Date

July 2020

Volume

30

Issue

7

Start / End Page

2667 / 2675

Location

United States

Related Subject Headings

  • Surgery
  • Obesity, Morbid
  • Norway
  • Middle Aged
  • Humans
  • Gastroesophageal Reflux
  • Female
  • Diabetes Mellitus, Type 2
  • Cross-Sectional Studies
  • Adult