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Integrin-β1 is required for the renal cystogenesis caused by ciliary defects.

Publication ,  Journal Article
Yoo, M; Barisoni, LMC; Lee, K; Gusella, GL
Published in: Am J Physiol Renal Physiol
May 1, 2020

Defects in the function of primary cilia are commonly associated with the development of renal cysts. On the other hand, the intact cilium appears to contribute a cystogenic signal whose effectors remain unclear. As integrin-β1 is required for the cystogenesis caused by the deletion of the polycystin 1 gene, we asked whether it would be similarly important in the cystogenetic process caused by other ciliary defects. We addressed this question by investigating the effect of integrin-β1 deletion in a ciliopathy genetic model in which the Ift88 gene, a component of complex B of intraflagellar transport that is required for the proper assembly of cilia, is specifically ablated in principal cells of the collecting ducts. We showed that the renal cystogenesis caused by loss of Ift88 is prevented when integrin-β1 is simultaneously depleted. In parallel, pathogenetic manifestations of the disease, such as increased inflammatory infiltrate and fibrosis, were also significantly reduced. Overall, our data indicate that integrin-β1 is also required for the renal cystogenesis caused by ciliary defects and point to integrin-β1-controlled pathways as common drivers of the disease and as possible targets to interfere with the cystogenesis caused by ciliary defects.

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Published In

Am J Physiol Renal Physiol

DOI

EISSN

1522-1466

Publication Date

May 1, 2020

Volume

318

Issue

5

Start / End Page

F1306 / F1312

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Tumor Suppressor Proteins
  • Signal Transduction
  • Mice, Knockout
  • Macrophages
  • Kidney Diseases, Cystic
  • Kidney
  • Integrin beta1
  • Inflammation Mediators
  • Fibrosis
 

Citation

APA
Chicago
ICMJE
MLA
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Yoo, M., Barisoni, L. M. C., Lee, K., & Gusella, G. L. (2020). Integrin-β1 is required for the renal cystogenesis caused by ciliary defects. Am J Physiol Renal Physiol, 318(5), F1306–F1312. https://doi.org/10.1152/ajprenal.00070.2020
Yoo, Miran, Laura M. C. Barisoni, Kyung Lee, and G Luca Gusella. “Integrin-β1 is required for the renal cystogenesis caused by ciliary defects.Am J Physiol Renal Physiol 318, no. 5 (May 1, 2020): F1306–12. https://doi.org/10.1152/ajprenal.00070.2020.
Yoo M, Barisoni LMC, Lee K, Gusella GL. Integrin-β1 is required for the renal cystogenesis caused by ciliary defects. Am J Physiol Renal Physiol. 2020 May 1;318(5):F1306–12.
Yoo, Miran, et al. “Integrin-β1 is required for the renal cystogenesis caused by ciliary defects.Am J Physiol Renal Physiol, vol. 318, no. 5, May 2020, pp. F1306–12. Pubmed, doi:10.1152/ajprenal.00070.2020.
Yoo M, Barisoni LMC, Lee K, Gusella GL. Integrin-β1 is required for the renal cystogenesis caused by ciliary defects. Am J Physiol Renal Physiol. 2020 May 1;318(5):F1306–F1312.

Published In

Am J Physiol Renal Physiol

DOI

EISSN

1522-1466

Publication Date

May 1, 2020

Volume

318

Issue

5

Start / End Page

F1306 / F1312

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Tumor Suppressor Proteins
  • Signal Transduction
  • Mice, Knockout
  • Macrophages
  • Kidney Diseases, Cystic
  • Kidney
  • Integrin beta1
  • Inflammation Mediators
  • Fibrosis