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Thermogenesis in Adipose Tissue Activated by Thyroid Hormone.

Publication ,  Journal Article
Yau, WW; Yen, PM
Published in: Int J Mol Sci
April 24, 2020

Thermogenesis is the production of heat that occurs in all warm-blooded animals. During cold exposure, there is obligatory thermogenesis derived from body metabolism as well as adaptive thermogenesis through shivering and non-shivering mechanisms. The latter mainly occurs in brown adipose tissue (BAT) and muscle; however, white adipose tissue (WAT) also can undergo browning via adrenergic stimulation to acquire thermogenic potential. Thyroid hormone (TH) also exerts profound effects on thermoregulation, as decreased body temperature and increased body temperature occur during hypothyroidism and hyperthyroidism, respectively. We have termed the TH-mediated thermogenesis under thermoneutral conditions "activated" thermogenesis. TH acts on the brown and/or white adipose tissues to induce uncoupled respiration through the induction of the uncoupling protein (Ucp1) to generate heat. TH acts centrally to activate the BAT and browning through the sympathetic nervous system. However, recent studies also show that TH acts peripherally on the BAT to directly stimulate Ucp1 expression and thermogenesis through an autophagy-dependent mechanism. Additionally, THs can exert Ucp1-independent effects on thermogenesis, most likely through activation of exothermic metabolic pathways. This review summarizes thermogenic effects of THs on adipose tissues.

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Published In

Int J Mol Sci

DOI

EISSN

1422-0067

Publication Date

April 24, 2020

Volume

21

Issue

8

Location

Switzerland

Related Subject Headings

  • Thyroid Hormones
  • Thermogenesis
  • Oxidation-Reduction
  • Mitochondria
  • Humans
  • Glucose
  • Energy Metabolism
  • Chemical Physics
  • Animals
  • Adipose Tissue, White
 

Citation

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Yau, W. W., & Yen, P. M. (2020). Thermogenesis in Adipose Tissue Activated by Thyroid Hormone. Int J Mol Sci, 21(8). https://doi.org/10.3390/ijms21083020
Yau, Winifred W., and Paul M. Yen. “Thermogenesis in Adipose Tissue Activated by Thyroid Hormone.Int J Mol Sci 21, no. 8 (April 24, 2020). https://doi.org/10.3390/ijms21083020.
Yau WW, Yen PM. Thermogenesis in Adipose Tissue Activated by Thyroid Hormone. Int J Mol Sci. 2020 Apr 24;21(8).
Yau, Winifred W., and Paul M. Yen. “Thermogenesis in Adipose Tissue Activated by Thyroid Hormone.Int J Mol Sci, vol. 21, no. 8, Apr. 2020. Pubmed, doi:10.3390/ijms21083020.
Yau WW, Yen PM. Thermogenesis in Adipose Tissue Activated by Thyroid Hormone. Int J Mol Sci. 2020 Apr 24;21(8).

Published In

Int J Mol Sci

DOI

EISSN

1422-0067

Publication Date

April 24, 2020

Volume

21

Issue

8

Location

Switzerland

Related Subject Headings

  • Thyroid Hormones
  • Thermogenesis
  • Oxidation-Reduction
  • Mitochondria
  • Humans
  • Glucose
  • Energy Metabolism
  • Chemical Physics
  • Animals
  • Adipose Tissue, White