Skip to main content
Journal cover image

Identifying clinically meaningful severity categories for PROMIS pediatric measures of anxiety, mobility, fatigue, and depressive symptoms in juvenile idiopathic arthritis and childhood-onset systemic lupus erythematosus.

Publication ,  Journal Article
Mann, CM; Schanberg, LE; Wang, M; von Scheven, E; Lucas, N; Hernandez, A; Ringold, S; Reeve, BB
Published in: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
September 2020

A key limitation to widespread adoption of patient-reported outcome (PRO) measures is the lack of interpretability of scores. We aim to identify clinical severity thresholds to distinguish categories of no problems, mild, moderate, and severe along the PROMIS® Pediatric T-score metric for measures of anxiety, mobility, fatigue, and depressive symptoms for use in populations with juvenile idiopathic arthritis (JIA) and childhood-onset systemic lupus erythematosus (cSLE).We used a modified standard setting methodology from educational testing to identify clinical severity thresholds (clinical cut scores). Using item response theory-based parameters from PROMIS item banks, we developed a series of clinical vignettes that represented different severity or ability levels along the PROMIS Pediatric T-score metric. In stakeholder workshops, participants worked individually and together to reach consensus on clinical cut scores. Median cut-score placements were taken when consensus was not reached. Focus groups were recorded and qualitative analysis was conducted to identify decision-making processes.Nine adolescents (age 13-17 years) with JIA (33% female) and their caregivers, five adolescents (age 14-16 years) with cSLE (100% female) and their caregivers, and 12 pediatric rheumatologists (75% female) participated in bookmarking workshops. Placement of thresholds for bookmarks was highly similar across stakeholder groups (differences from 0 to 5 points on the PROMIS t-score metric) for all but one bookmark placement.This study resulted in clinical thresholds for severity categories for PROMIS Pediatric measures of anxiety, mobility, fatigue, and depressive symptoms, providing greater interpretability of scores in JIA and cSLE populations.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

DOI

EISSN

1573-2649

ISSN

0962-9343

Publication Date

September 2020

Volume

29

Issue

9

Start / End Page

2573 / 2584

Related Subject Headings

  • Quality of Life
  • Patient Reported Outcome Measures
  • Male
  • Lupus Erythematosus, Systemic
  • Humans
  • Health Policy & Services
  • Female
  • Depression
  • Child
  • Arthritis, Juvenile
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mann, C. M., Schanberg, L. E., Wang, M., von Scheven, E., Lucas, N., Hernandez, A., … Reeve, B. B. (2020). Identifying clinically meaningful severity categories for PROMIS pediatric measures of anxiety, mobility, fatigue, and depressive symptoms in juvenile idiopathic arthritis and childhood-onset systemic lupus erythematosus. Quality of Life Research : An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, 29(9), 2573–2584. https://doi.org/10.1007/s11136-020-02513-6
Mann, C. M., L. E. Schanberg, M. Wang, E. von Scheven, N. Lucas, A. Hernandez, S. Ringold, and B. B. Reeve. “Identifying clinically meaningful severity categories for PROMIS pediatric measures of anxiety, mobility, fatigue, and depressive symptoms in juvenile idiopathic arthritis and childhood-onset systemic lupus erythematosus.Quality of Life Research : An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation 29, no. 9 (September 2020): 2573–84. https://doi.org/10.1007/s11136-020-02513-6.
Mann CM, Schanberg LE, Wang M, von Scheven E, Lucas N, Hernandez A, et al. Identifying clinically meaningful severity categories for PROMIS pediatric measures of anxiety, mobility, fatigue, and depressive symptoms in juvenile idiopathic arthritis and childhood-onset systemic lupus erythematosus. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 2020 Sep;29(9):2573–84.
Mann, C. M., et al. “Identifying clinically meaningful severity categories for PROMIS pediatric measures of anxiety, mobility, fatigue, and depressive symptoms in juvenile idiopathic arthritis and childhood-onset systemic lupus erythematosus.Quality of Life Research : An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, vol. 29, no. 9, Sept. 2020, pp. 2573–84. Epmc, doi:10.1007/s11136-020-02513-6.
Mann CM, Schanberg LE, Wang M, von Scheven E, Lucas N, Hernandez A, Ringold S, Reeve BB. Identifying clinically meaningful severity categories for PROMIS pediatric measures of anxiety, mobility, fatigue, and depressive symptoms in juvenile idiopathic arthritis and childhood-onset systemic lupus erythematosus. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 2020 Sep;29(9):2573–2584.
Journal cover image

Published In

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

DOI

EISSN

1573-2649

ISSN

0962-9343

Publication Date

September 2020

Volume

29

Issue

9

Start / End Page

2573 / 2584

Related Subject Headings

  • Quality of Life
  • Patient Reported Outcome Measures
  • Male
  • Lupus Erythematosus, Systemic
  • Humans
  • Health Policy & Services
  • Female
  • Depression
  • Child
  • Arthritis, Juvenile