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Longitudinal study of anthropometry in Fontan survivors: Pediatric Heart Network Fontan study.

Publication ,  Journal Article
Lambert, LM; McCrindle, BW; Pemberton, VL; Hollenbeck-Pringle, D; Atz, AM; Ravishankar, C; Campbell, MJ; Dunbar-Masterson, C; Uzark, K ...
Published in: Am Heart J
June 2020

BACKGROUND: Growth abnormalities in single-ventricle survivors may reduce quality of life (QoL) and exercise capacity. METHODS: This multicenter, longitudinal analysis evaluated changes in height and body mass index (BMI) compared to population norms and their relationship to mortality, ventricular morphology, QoL, and exercise capacity in the Pediatric Heart Network Fontan studies. RESULTS: Fontan 1 (F1) included 546 participants (12 ± 3.4 years); Fontan 2 (F2), 427 (19 ± 3.4 years); and Fontan 3 (F3), 362 (21 ± 3.5 years), with ~60% male at each time point. Height z-score was -0.67 ± -1.27, -0.60 ± 1.34, and- 0.43 ± 1.14 at F1-F3, lower compared to norms at all time points (P ≤ .001). BMI z-score was similar to population norms. Compared to survivors, participants who died had lower height z-score (P ≤ .001). Participants with dominant right ventricle (n = 112) had lower height z-score (P ≤ .004) compared to dominant left (n = 186) or mixed (n = 64) ventricular morphologies. Higher height z-score was associated with higher Pediatric Quality of Life Inventory for the total score (slope = 2.82 ± 0.52; P ≤ .001). Increase in height z-score (F1 to F3) was associated with increased oxygen consumption (slope = 2.61 ± 1.08; P = .02), whereas, for participants >20 years old, an increase in BMI (F1 to F3) was associated with a decrease in oxygen consumption (slope = -1.25 ± 0.33; P ≤ .001). CONCLUSIONS: Fontan survivors, especially those with right ventricular morphology, are shorter when compared to the normal population but have similar BMI. Shorter stature was associated with worse survival. An increase in height z-score over the course of the study was associated with better QoL and exercise capacity; an increase in BMI was associated with worse exercise capacity.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

June 2020

Volume

224

Start / End Page

192 / 200

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Survival Rate
  • Retrospective Studies
  • Quality of Life
  • Prognosis
  • Postoperative Period
  • Male
  • Humans
  • Heart Ventricles
 

Citation

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Lambert, L. M., McCrindle, B. W., Pemberton, V. L., Hollenbeck-Pringle, D., Atz, A. M., Ravishankar, C., … Pediatric Heart Network Investigators, . (2020). Longitudinal study of anthropometry in Fontan survivors: Pediatric Heart Network Fontan study. Am Heart J, 224, 192–200. https://doi.org/10.1016/j.ahj.2020.03.022
Lambert, Linda M., Brian W. McCrindle, Victoria L. Pemberton, Danielle Hollenbeck-Pringle, Andrew M. Atz, Chitra Ravishankar, M Jay Campbell, et al. “Longitudinal study of anthropometry in Fontan survivors: Pediatric Heart Network Fontan study.Am Heart J 224 (June 2020): 192–200. https://doi.org/10.1016/j.ahj.2020.03.022.
Lambert LM, McCrindle BW, Pemberton VL, Hollenbeck-Pringle D, Atz AM, Ravishankar C, et al. Longitudinal study of anthropometry in Fontan survivors: Pediatric Heart Network Fontan study. Am Heart J. 2020 Jun;224:192–200.
Lambert, Linda M., et al. “Longitudinal study of anthropometry in Fontan survivors: Pediatric Heart Network Fontan study.Am Heart J, vol. 224, June 2020, pp. 192–200. Pubmed, doi:10.1016/j.ahj.2020.03.022.
Lambert LM, McCrindle BW, Pemberton VL, Hollenbeck-Pringle D, Atz AM, Ravishankar C, Campbell MJ, Dunbar-Masterson C, Uzark K, Rolland M, Trachtenberg FL, Menon SC, Pediatric Heart Network Investigators. Longitudinal study of anthropometry in Fontan survivors: Pediatric Heart Network Fontan study. Am Heart J. 2020 Jun;224:192–200.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

June 2020

Volume

224

Start / End Page

192 / 200

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Survival Rate
  • Retrospective Studies
  • Quality of Life
  • Prognosis
  • Postoperative Period
  • Male
  • Humans
  • Heart Ventricles