RGEN Editing of RNA and DNA: The Long and Winding Road from Catalytic RNAs to CRISPR to the Clinic.
Publication
, Journal Article
Sullenger, BA
Published in: Cell
May 28, 2020
The first clinical studies utilizing RNA-guided endonucleases (RGENs) to therapeutically edit RNA and DNA in cancer patients were recently published. These groundbreaking technological advances promise to revolutionize genetic therapy and, as I discuss, represent the culmination of decades of innovative work to engineer RGENs for such editing applications.
Duke Scholars
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Published In
Cell
DOI
EISSN
1097-4172
Publication Date
May 28, 2020
Volume
181
Issue
5
Start / End Page
955 / 960
Location
United States
Related Subject Headings
- RNA, Guide, CRISPR-Cas Systems
- RNA, Catalytic
- RNA Editing
- RNA
- Mutation
- Gene Editing
- Endonucleases
- Developmental Biology
- DNA
- Clustered Regularly Interspaced Short Palindromic Repeats
Citation
APA
Chicago
ICMJE
MLA
NLM
Sullenger, B. A. (2020). RGEN Editing of RNA and DNA: The Long and Winding Road from Catalytic RNAs to CRISPR to the Clinic. Cell, 181(5), 955–960. https://doi.org/10.1016/j.cell.2020.04.050
Sullenger, Bruce A. “RGEN Editing of RNA and DNA: The Long and Winding Road from Catalytic RNAs to CRISPR to the Clinic.” Cell 181, no. 5 (May 28, 2020): 955–60. https://doi.org/10.1016/j.cell.2020.04.050.
Sullenger BA. RGEN Editing of RNA and DNA: The Long and Winding Road from Catalytic RNAs to CRISPR to the Clinic. Cell. 2020 May 28;181(5):955–60.
Sullenger, Bruce A. “RGEN Editing of RNA and DNA: The Long and Winding Road from Catalytic RNAs to CRISPR to the Clinic.” Cell, vol. 181, no. 5, May 2020, pp. 955–60. Pubmed, doi:10.1016/j.cell.2020.04.050.
Sullenger BA. RGEN Editing of RNA and DNA: The Long and Winding Road from Catalytic RNAs to CRISPR to the Clinic. Cell. 2020 May 28;181(5):955–960.
Published In
Cell
DOI
EISSN
1097-4172
Publication Date
May 28, 2020
Volume
181
Issue
5
Start / End Page
955 / 960
Location
United States
Related Subject Headings
- RNA, Guide, CRISPR-Cas Systems
- RNA, Catalytic
- RNA Editing
- RNA
- Mutation
- Gene Editing
- Endonucleases
- Developmental Biology
- DNA
- Clustered Regularly Interspaced Short Palindromic Repeats