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Time required for elimination of Neisseria gonorrhoeae from the urogenital tract in men with symptomatic urethritis: comparison of oral and intramuscular single-dose therapy.

Publication ,  Journal Article
Haizlip, J; Isbey, SF; Hamilton, HA; Jerse, AE; Leone, PA; Davis, RH; Cohen, MS
Published in: Sex Transm Dis
1995

BACKGROUND AND OBJECTIVES: The spread of sexually transmitted diseases (STDs), including gonorrhea, is affected by the duration of infection. Oral antibiotic therapy for gonococcal infection has been shown to be as effective as conventional intramuscular injection with ceftriaxone. Rapid cure would be expected to limit further spread of gonorrhea. However, the speed with which Neisseria gonorrhoeae is eliminated from the urogenital tract has not been evaluated. GOAL OF THIS STUDY: To determine the time required for elimination of Neisseria gonorrhoeae for the urine, mucosa, and semen in male subjects after treatment with ceftriaxone (250 mg intramuscularly), ciprofloxacin (500 mg by mouth, single dose) or cefixime (400 mg by mouth, single dose.) RESULTS: In 14 subjects, gonococci were eliminated from the urine within 4 hours of therapy and the mucosa within 24 hours after therapy. In 9 additional subjects, gonococci were eliminated from the semen by 24 hours after therapy. CONCLUSIONS: These results support the efficacy of single-dose oral therapy for gonorrhea and suggest that earlier follow-up for proof of cure in clinical trials of new antibiotics for gonorrhea may be acceptable. Rapid elimination of gonorrhea reduces the risk for continued transmission of the organism.

Duke Scholars

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Published In

Sex Transm Dis

DOI

ISSN

0148-5717

Publication Date

1995

Volume

22

Issue

3

Start / End Page

145 / 148

Location

United States

Related Subject Headings

  • Urethritis
  • Time Factors
  • Semen
  • Public Health
  • Neisseria gonorrhoeae
  • Middle Aged
  • Male
  • Injections, Intramuscular
  • Humans
  • Gonorrhea
 

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Haizlip, J., Isbey, S. F., Hamilton, H. A., Jerse, A. E., Leone, P. A., Davis, R. H., & Cohen, M. S. (1995). Time required for elimination of Neisseria gonorrhoeae from the urogenital tract in men with symptomatic urethritis: comparison of oral and intramuscular single-dose therapy. Sex Transm Dis, 22(3), 145–148. https://doi.org/10.1097/00007435-199505000-00002
Haizlip, J., S. F. Isbey, H. A. Hamilton, A. E. Jerse, P. A. Leone, R. H. Davis, and M. S. Cohen. “Time required for elimination of Neisseria gonorrhoeae from the urogenital tract in men with symptomatic urethritis: comparison of oral and intramuscular single-dose therapy.Sex Transm Dis 22, no. 3 (1995): 145–48. https://doi.org/10.1097/00007435-199505000-00002.
Haizlip, J., et al. “Time required for elimination of Neisseria gonorrhoeae from the urogenital tract in men with symptomatic urethritis: comparison of oral and intramuscular single-dose therapy.Sex Transm Dis, vol. 22, no. 3, 1995, pp. 145–48. Pubmed, doi:10.1097/00007435-199505000-00002.

Published In

Sex Transm Dis

DOI

ISSN

0148-5717

Publication Date

1995

Volume

22

Issue

3

Start / End Page

145 / 148

Location

United States

Related Subject Headings

  • Urethritis
  • Time Factors
  • Semen
  • Public Health
  • Neisseria gonorrhoeae
  • Middle Aged
  • Male
  • Injections, Intramuscular
  • Humans
  • Gonorrhea