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Inner ear delivery: Challenges and opportunities.

Publication ,  Journal Article
Szeto, B; Chiang, H; Valentini, C; Yu, M; Kysar, JW; Lalwani, AK
Published in: Laryngoscope investigative otolaryngology
February 2020

The treatment of inner ear disorders remains challenging due to anatomic barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent advances and strategies for overcoming these barriers and to discuss promising future avenues for investigation.The databases used were PubMed, EMBASE, and Web of Science.Although some studies aimed to improve systemic delivery using nanoparticle systems, the majority enhanced local delivery using hydrogels, nanoparticles, and microneedles. Developments in direct intracochlear delivery include intracochlear injection and intracochlear implants.In the absence of a systemic drug that targets only the inner ear, the best alternative is local delivery that harnesses a combination of new strategies to overcome anatomic barriers. The combination of microneedle technology with hydrogel and nanoparticle delivery is a promising area for future investigation.NA.

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Published In

Laryngoscope investigative otolaryngology

DOI

EISSN

2378-8038

ISSN

2378-8038

Publication Date

February 2020

Volume

5

Issue

1

Start / End Page

122 / 131

Related Subject Headings

  • 090304 Medical Devices
 

Citation

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Szeto, B., Chiang, H., Valentini, C., Yu, M., Kysar, J. W., & Lalwani, A. K. (2020). Inner ear delivery: Challenges and opportunities. Laryngoscope Investigative Otolaryngology, 5(1), 122–131. https://doi.org/10.1002/lio2.336
Szeto, Betsy, Harry Chiang, Chris Valentini, Michelle Yu, Jeffrey W. Kysar, and Anil K. Lalwani. “Inner ear delivery: Challenges and opportunities.Laryngoscope Investigative Otolaryngology 5, no. 1 (February 2020): 122–31. https://doi.org/10.1002/lio2.336.
Szeto B, Chiang H, Valentini C, Yu M, Kysar JW, Lalwani AK. Inner ear delivery: Challenges and opportunities. Laryngoscope investigative otolaryngology. 2020 Feb;5(1):122–31.
Szeto, Betsy, et al. “Inner ear delivery: Challenges and opportunities.Laryngoscope Investigative Otolaryngology, vol. 5, no. 1, Feb. 2020, pp. 122–31. Epmc, doi:10.1002/lio2.336.
Szeto B, Chiang H, Valentini C, Yu M, Kysar JW, Lalwani AK. Inner ear delivery: Challenges and opportunities. Laryngoscope investigative otolaryngology. 2020 Feb;5(1):122–131.
Journal cover image

Published In

Laryngoscope investigative otolaryngology

DOI

EISSN

2378-8038

ISSN

2378-8038

Publication Date

February 2020

Volume

5

Issue

1

Start / End Page

122 / 131

Related Subject Headings

  • 090304 Medical Devices