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Ten years of donor-derived disease: A report of the disease transmission advisory committee.

Publication ,  Journal Article
Kaul, DR; Vece, G; Blumberg, E; La Hoz, RM; Ison, MG; Green, M; Pruett, T; Nalesnik, MA; Tlusty, SM; Wilk, AR; Wolfe, CR; Michaels, MG
Published in: Am J Transplant
February 2021

Despite clinical and laboratory screening of potential donors for transmissible disease, unexpected transmission of disease from donor to recipient remains an inherent risk of organ transplantation. The Disease Transmission Advisory Committee (DTAC) was created to review and classify reports of potential disease transmission and use this information to inform national policy and improve patient safety. From January 1, 2008 to December 31, 2017, the DTAC received 2185 reports; 335 (15%) were classified as a proven/probable donor transmission event. Infections were transmitted most commonly (67%), followed by malignancies (29%), and other disease processes (6%). Forty-six percent of recipients receiving organs from a donor that transmitted disease to at least 1 recipient developed a donor-derived disease (DDD). Sixty-seven percent of recipients developed symptoms of DDD within 30 days of transplantation, and all bacterial infections were recognized within 45 days. Graft loss or death occurred in about one third of recipients with DDD, with higher rates associated with malignancy transmission and parasitic and fungal diseases. Unexpected DDD was rare, occurring in 0.18% of all transplant recipients. These findings will help focus future efforts to recognize and prevent DDD.

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Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

February 2021

Volume

21

Issue

2

Start / End Page

689 / 702

Location

United States

Related Subject Headings

  • Transplant Recipients
  • Tissue Donors
  • Surgery
  • Organ Transplantation
  • Humans
  • Communicable Diseases
  • Advisory Committees
  • 3204 Immunology
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kaul, D. R., Vece, G., Blumberg, E., La Hoz, R. M., Ison, M. G., Green, M., … Michaels, M. G. (2021). Ten years of donor-derived disease: A report of the disease transmission advisory committee. Am J Transplant, 21(2), 689–702. https://doi.org/10.1111/ajt.16178
Kaul, Daniel R., Gabe Vece, Emily Blumberg, Ricardo M. La Hoz, Michael G. Ison, Michael Green, Timothy Pruett, et al. “Ten years of donor-derived disease: A report of the disease transmission advisory committee.Am J Transplant 21, no. 2 (February 2021): 689–702. https://doi.org/10.1111/ajt.16178.
Kaul DR, Vece G, Blumberg E, La Hoz RM, Ison MG, Green M, et al. Ten years of donor-derived disease: A report of the disease transmission advisory committee. Am J Transplant. 2021 Feb;21(2):689–702.
Kaul, Daniel R., et al. “Ten years of donor-derived disease: A report of the disease transmission advisory committee.Am J Transplant, vol. 21, no. 2, Feb. 2021, pp. 689–702. Pubmed, doi:10.1111/ajt.16178.
Kaul DR, Vece G, Blumberg E, La Hoz RM, Ison MG, Green M, Pruett T, Nalesnik MA, Tlusty SM, Wilk AR, Wolfe CR, Michaels MG. Ten years of donor-derived disease: A report of the disease transmission advisory committee. Am J Transplant. 2021 Feb;21(2):689–702.
Journal cover image

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

February 2021

Volume

21

Issue

2

Start / End Page

689 / 702

Location

United States

Related Subject Headings

  • Transplant Recipients
  • Tissue Donors
  • Surgery
  • Organ Transplantation
  • Humans
  • Communicable Diseases
  • Advisory Committees
  • 3204 Immunology
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences