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Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe COVID-19: A case report.

Publication ,  Journal Article
Franzetti, M; Pozzetti, U; Carugati, M; Pandolfo, A; Molteni, C; Faccioli, P; Castaldo, G; Longoni, E; Ormas, V; Iemoli, E; Piconi, S
Published in: Int J Infect Dis
August 2020

We report the first successful treatment with the IL-1 receptor antagonist anakinra, in association with the most promising and available antiviral therapy, of a severe case of novel coronavirus disease 2019 (COVID-19). We describe the diagnosis, clinical course, and management of the case, including the respiratory failure at presentation, the progression to a scenario characterized by profound inflammatory dysregulation similar to that observed during macrophage activation syndrome, and the clinical improvement after treatment with the IL-1 receptor antagonist anakinra. This case highlights the high tolerability and the interesting immunomodulatory profile of the IL-1 receptor antagonist anakinra in the setting of severe COVID-19 associated with remdesivir therapy. Further studies are needed to confirm the safety and efficacy of this combination strategy in the treatment of this emerging infection.

Duke Scholars

Published In

Int J Infect Dis

DOI

EISSN

1878-3511

Publication Date

August 2020

Volume

97

Start / End Page

215 / 218

Location

Canada

Related Subject Headings

  • SARS-CoV-2
  • Respiratory Insufficiency
  • Receptors, Interleukin-1
  • Pneumonia, Viral
  • Pandemics
  • Middle Aged
  • Microbiology
  • Male
  • Interleukin 1 Receptor Antagonist Protein
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Franzetti, M., Pozzetti, U., Carugati, M., Pandolfo, A., Molteni, C., Faccioli, P., … Piconi, S. (2020). Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe COVID-19: A case report. Int J Infect Dis, 97, 215–218. https://doi.org/10.1016/j.ijid.2020.05.050

Published In

Int J Infect Dis

DOI

EISSN

1878-3511

Publication Date

August 2020

Volume

97

Start / End Page

215 / 218

Location

Canada

Related Subject Headings

  • SARS-CoV-2
  • Respiratory Insufficiency
  • Receptors, Interleukin-1
  • Pneumonia, Viral
  • Pandemics
  • Middle Aged
  • Microbiology
  • Male
  • Interleukin 1 Receptor Antagonist Protein
  • Humans