Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe COVID-19: A case report.
We report the first successful treatment with the IL-1 receptor antagonist anakinra, in association with the most promising and available antiviral therapy, of a severe case of novel coronavirus disease 2019 (COVID-19). We describe the diagnosis, clinical course, and management of the case, including the respiratory failure at presentation, the progression to a scenario characterized by profound inflammatory dysregulation similar to that observed during macrophage activation syndrome, and the clinical improvement after treatment with the IL-1 receptor antagonist anakinra. This case highlights the high tolerability and the interesting immunomodulatory profile of the IL-1 receptor antagonist anakinra in the setting of severe COVID-19 associated with remdesivir therapy. Further studies are needed to confirm the safety and efficacy of this combination strategy in the treatment of this emerging infection.
Duke Scholars
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Related Subject Headings
- SARS-CoV-2
- Respiratory Insufficiency
- Receptors, Interleukin-1
- Pneumonia, Viral
- Pandemics
- Middle Aged
- Microbiology
- Male
- Interleukin 1 Receptor Antagonist Protein
- Humans
Citation
Published In
DOI
EISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- SARS-CoV-2
- Respiratory Insufficiency
- Receptors, Interleukin-1
- Pneumonia, Viral
- Pandemics
- Middle Aged
- Microbiology
- Male
- Interleukin 1 Receptor Antagonist Protein
- Humans