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Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide are associated with protection against infection from household contacts of patients with cholera in Bangladesh.

Publication ,  Journal Article
Patel, SM; Rahman, MA; Mohasin, M; Riyadh, MA; Leung, DT; Alam, MM; Chowdhury, F; Khan, AI; Weil, AA; Aktar, A; Nazim, M; LaRocque, RC ...
Published in: Clin Vaccine Immunol
June 2012

Vibrio cholerae O1 causes cholera, a dehydrating diarrheal disease. We have previously shown that V. cholerae-specific memory B cell responses develop after cholera infection, and we hypothesize that these mediate long-term protective immunity against cholera. We prospectively followed household contacts of cholera patients to determine whether the presence of circulating V. cholerae O1 antigen-specific memory B cells on enrollment was associated with protection against V. cholerae infection over a 30-day period. Two hundred thirty-six household contacts of 122 index patients with cholera were enrolled. The presence of lipopolysaccharide (LPS)-specific IgG memory B cells in peripheral blood on study entry was associated with a 68% decrease in the risk of infection in household contacts (P = 0.032). No protection was associated with cholera toxin B subunit (CtxB)-specific memory B cells or IgA memory B cells specific to LPS. These results suggest that LPS-specific IgG memory B cells may be important in protection against infection with V. cholerae O1.

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Published In

Clin Vaccine Immunol

DOI

EISSN

1556-679X

Publication Date

June 2012

Volume

19

Issue

6

Start / End Page

842 / 848

Location

United States

Related Subject Headings

  • Young Adult
  • Vibrio cholerae O1
  • Microbiology
  • Male
  • Lipopolysaccharides
  • Immunology
  • Immunologic Memory
  • Immunoglobulin G
  • Humans
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Patel, S. M., Rahman, M. A., Mohasin, M., Riyadh, M. A., Leung, D. T., Alam, M. M., … Harris, J. B. (2012). Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide are associated with protection against infection from household contacts of patients with cholera in Bangladesh. Clin Vaccine Immunol, 19(6), 842–848. https://doi.org/10.1128/CVI.00037-12
Patel, Sweta M., Mohammad Arif Rahman, M. Mohasin, M Asrafuzzaman Riyadh, Daniel T. Leung, Mohammad Murshid Alam, Fahima Chowdhury, et al. “Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide are associated with protection against infection from household contacts of patients with cholera in Bangladesh.Clin Vaccine Immunol 19, no. 6 (June 2012): 842–48. https://doi.org/10.1128/CVI.00037-12.
Patel, Sweta M., et al. “Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide are associated with protection against infection from household contacts of patients with cholera in Bangladesh.Clin Vaccine Immunol, vol. 19, no. 6, June 2012, pp. 842–48. Pubmed, doi:10.1128/CVI.00037-12.
Patel SM, Rahman MA, Mohasin M, Riyadh MA, Leung DT, Alam MM, Chowdhury F, Khan AI, Weil AA, Aktar A, Nazim M, LaRocque RC, Ryan ET, Calderwood SB, Qadri F, Harris JB. Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide are associated with protection against infection from household contacts of patients with cholera in Bangladesh. Clin Vaccine Immunol. 2012 Jun;19(6):842–848.

Published In

Clin Vaccine Immunol

DOI

EISSN

1556-679X

Publication Date

June 2012

Volume

19

Issue

6

Start / End Page

842 / 848

Location

United States

Related Subject Headings

  • Young Adult
  • Vibrio cholerae O1
  • Microbiology
  • Male
  • Lipopolysaccharides
  • Immunology
  • Immunologic Memory
  • Immunoglobulin G
  • Humans
  • Follow-Up Studies