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Cell-type specific regulation of gene expression by simian virus 40 T antigens.

Publication ,  Journal Article
Cantalupo, PG; Sáenz-Robles, MT; Rathi, AV; Beerman, RW; Patterson, WH; Whitehead, RH; Pipas, JM
Published in: Virology
March 2009

SV40 transforms cells through the action of two oncoproteins, large T antigen and small t antigen. Small t antigen targets phosphatase PP2A, while large T antigen stimulates cell proliferation and survival by action on multiple proteins, including the tumor suppressors Rb and p53. Large T antigen also binds components of the transcription initiation complex and several transcription factors. We examined global gene expression in SV40-transformed mouse embryo fibroblasts, and in enterocytes obtained from transgenic mice. SV40 transformation alters the expression of approximately 800 cellular genes in both systems. Much of this regulation is observed in both MEFs and enterocytes and is consistent with T antigen action on the Rb-E2F pathway. However, the regulation of many genes is cell-type specific, suggesting that unique signaling pathways are activated in different cell types upon transformation, and that the consequences of SV40 transformation depends on the type of cell targeted.

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Published In

Virology

DOI

EISSN

1096-0341

ISSN

0042-6822

Publication Date

March 2009

Volume

386

Issue

1

Start / End Page

183 / 191

Related Subject Headings

  • Virology
  • Simian virus 40
  • Mice, Transgenic
  • Mice
  • Gene Expression Regulation
  • Gene Expression Profiling
  • Fibroblasts
  • Enterocytes
  • Cells, Cultured
  • Antigens, Polyomavirus Transforming
 

Citation

APA
Chicago
ICMJE
MLA
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Cantalupo, P. G., Sáenz-Robles, M. T., Rathi, A. V., Beerman, R. W., Patterson, W. H., Whitehead, R. H., & Pipas, J. M. (2009). Cell-type specific regulation of gene expression by simian virus 40 T antigens. Virology, 386(1), 183–191. https://doi.org/10.1016/j.virol.2008.12.038
Cantalupo, Paul G., Maria Teresa Sáenz-Robles, Abhilasha V. Rathi, Rebecca W. Beerman, William H. Patterson, Robert H. Whitehead, and James M. Pipas. “Cell-type specific regulation of gene expression by simian virus 40 T antigens.Virology 386, no. 1 (March 2009): 183–91. https://doi.org/10.1016/j.virol.2008.12.038.
Cantalupo PG, Sáenz-Robles MT, Rathi AV, Beerman RW, Patterson WH, Whitehead RH, et al. Cell-type specific regulation of gene expression by simian virus 40 T antigens. Virology. 2009 Mar;386(1):183–91.
Cantalupo, Paul G., et al. “Cell-type specific regulation of gene expression by simian virus 40 T antigens.Virology, vol. 386, no. 1, Mar. 2009, pp. 183–91. Epmc, doi:10.1016/j.virol.2008.12.038.
Cantalupo PG, Sáenz-Robles MT, Rathi AV, Beerman RW, Patterson WH, Whitehead RH, Pipas JM. Cell-type specific regulation of gene expression by simian virus 40 T antigens. Virology. 2009 Mar;386(1):183–191.
Journal cover image

Published In

Virology

DOI

EISSN

1096-0341

ISSN

0042-6822

Publication Date

March 2009

Volume

386

Issue

1

Start / End Page

183 / 191

Related Subject Headings

  • Virology
  • Simian virus 40
  • Mice, Transgenic
  • Mice
  • Gene Expression Regulation
  • Gene Expression Profiling
  • Fibroblasts
  • Enterocytes
  • Cells, Cultured
  • Antigens, Polyomavirus Transforming