Skip to main content

Association of Resting Heart Rate With Blood Pressure and Incident Hypertension Over 30 Years in Black and White Adults: The CARDIA Study.

Publication ,  Journal Article
Colangelo, LA; Yano, Y; Jacobs, DR; Lloyd-Jones, DM
Published in: Hypertension
September 2020

Few studies have assessed the association of resting heart rate (RHR) through young adulthood with incident hypertension by middle age. We investigated the association between RHR measured over 30 years with incident hypertension in a cohort of young Black and White men and women. A joint longitudinal time-to-event model consisting of a mixed random effects submodel, quadratic in follow-up time, and a survival submodel adjusted for confounders, was used to determine hazard ratios for a 10 bpm higher RHR. Race-sex specific effects were examined in a single joint model that included interactions of race-sex groups with longitudinal RHR. Out of 5115 participants enrolled in year 0 (1985-1986), after excluding prevalent cases of hypertension at baseline, 1615 men and 2273 women were included in the analytic cohort. Hypertension event rates per 1000 person-years were 42.5 and 25.7 in Black and White men, respectively, and 36.2 and 15.3 in Black and White women, respectively. The hazard ratios for a 10 bpm higher RHR were 1.47 (95% CI, 1.23-1.75), 1.51 (95% CI, 1.28-1.78), 1.48 (95% CI, 1.26-1.73), and 1.02, (95% CI, 0.89-1.17) for Black men, White men, White women, and Black women, respectively. Higher RHR during young adulthood is associated with a greater risk of incident hypertension by middle age. The association is similarly strong in Black men, White men, and White women, but absent in Black women, which may suggest racial differences in the effect of sympathetic nervous activity on hypertension among women.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

September 2020

Volume

76

Issue

3

Start / End Page

692 / 698

Location

United States

Related Subject Headings

  • White People
  • United States
  • Sympathetic Nervous System
  • Sex Factors
  • Risk Assessment
  • Rest
  • Prognosis
  • Probability
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Colangelo, L. A., Yano, Y., Jacobs, D. R., & Lloyd-Jones, D. M. (2020). Association of Resting Heart Rate With Blood Pressure and Incident Hypertension Over 30 Years in Black and White Adults: The CARDIA Study. Hypertension, 76(3), 692–698. https://doi.org/10.1161/HYPERTENSIONAHA.120.15233
Colangelo, Laura A., Yuichiro Yano, David R. Jacobs, and Donald M. Lloyd-Jones. “Association of Resting Heart Rate With Blood Pressure and Incident Hypertension Over 30 Years in Black and White Adults: The CARDIA Study.Hypertension 76, no. 3 (September 2020): 692–98. https://doi.org/10.1161/HYPERTENSIONAHA.120.15233.
Colangelo, Laura A., et al. “Association of Resting Heart Rate With Blood Pressure and Incident Hypertension Over 30 Years in Black and White Adults: The CARDIA Study.Hypertension, vol. 76, no. 3, Sept. 2020, pp. 692–98. Pubmed, doi:10.1161/HYPERTENSIONAHA.120.15233.

Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

September 2020

Volume

76

Issue

3

Start / End Page

692 / 698

Location

United States

Related Subject Headings

  • White People
  • United States
  • Sympathetic Nervous System
  • Sex Factors
  • Risk Assessment
  • Rest
  • Prognosis
  • Probability
  • Middle Aged
  • Male