Skip to main content
Journal cover image

Markers of Iron Flux during Testosterone-Mediated Erythropoiesis in Older Men with Unexplained or Iron-Deficiency Anemia.

Publication ,  Journal Article
Artz, AS; Stephens-Shields, AJ; Bhasin, S; Ellenberg, SS; Cohen, HJ; Snyder, PJ
Published in: J Clin Endocrinol Metab
November 1, 2020

CONTEXT: Testosterone treatment of hypogonadal men improves their hemoglobin, but the mechanism is not understood. OBJECTIVE: To investigate possible mechanisms by which testosterone stimulates erythropoiesis in hypogonadal older men with unexplained or iron-deficiency anemia. DESIGN: The Anemia Trial of The Testosterone Trials, a placebo-controlled study in older, hypogonadal men. SETTING: Twelve academic medical centers. PARTICIPANTS: A total of 95 hypogonadal men (testosterone < 275 ng/mL) ≥65 years with anemia (hemoglobin < 12.7 g/dL). They were classified as having unexplained (n = 58) or iron deficiency anemia (n = 37). INTERVENTION: Testosterone or placebo gel for 1 year. MAIN OUTCOME MEASURES: Markers of iron metabolism during the first 3 months of treatment. RESULTS: Testosterone replacement significantly (P < 0.001) increased hemoglobin in the 58 men who had unexplained anemia (adjusted mean difference 0.58 g/dL; 95% confidence interval, 0.31-0.85). Testosterone replacement tended to increase hemoglobin in the 37 men who had iron deficiency (0.38 g/dL; -0.19, 0.95), but the response was more variable and not statistically significant (P = 0.19). In men with unexplained anemia, testosterone replacement suppressed hepcidin (-8.2 ng/mL; -13.7, -2.7; P = 0.004) and ferritin (-19.6 µg/L; -32.8, -6.3; P = 0.004), but in men with iron deficiency, testosterone replacement did not. The decrease in hepcidin was moderately correlated with the increase in hemoglobin in the men with unexplained anemia (correlation coefficient -0.35, P = 0.01) but not in those with iron deficiency anemia (correlation coefficient -0.07, P = 0.73). CONCLUSIONS: Testosterone replacement of older hypogonadal men with unexplained anemia stimulates erythropoiesis associated with increased iron mobilization. This effect appears to be attenuated by iron deficiency.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

November 1, 2020

Volume

105

Issue

11

Start / End Page

3396 / 3403

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Testosterone
  • Male
  • Hypogonadism
  • Humans
  • Hormone Replacement Therapy
  • Hemoglobins
  • Erythropoiesis
  • Endocrinology & Metabolism
  • Anemia, Iron-Deficiency
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Artz, A. S., Stephens-Shields, A. J., Bhasin, S., Ellenberg, S. S., Cohen, H. J., & Snyder, P. J. (2020). Markers of Iron Flux during Testosterone-Mediated Erythropoiesis in Older Men with Unexplained or Iron-Deficiency Anemia. J Clin Endocrinol Metab, 105(11), 3396–3403. https://doi.org/10.1210/clinem/dgaa521
Artz, Andrew S., Alisa J. Stephens-Shields, Shalender Bhasin, Susan S. Ellenberg, Harvey J. Cohen, and Peter J. Snyder. “Markers of Iron Flux during Testosterone-Mediated Erythropoiesis in Older Men with Unexplained or Iron-Deficiency Anemia.J Clin Endocrinol Metab 105, no. 11 (November 1, 2020): 3396–3403. https://doi.org/10.1210/clinem/dgaa521.
Artz AS, Stephens-Shields AJ, Bhasin S, Ellenberg SS, Cohen HJ, Snyder PJ. Markers of Iron Flux during Testosterone-Mediated Erythropoiesis in Older Men with Unexplained or Iron-Deficiency Anemia. J Clin Endocrinol Metab. 2020 Nov 1;105(11):3396–403.
Artz, Andrew S., et al. “Markers of Iron Flux during Testosterone-Mediated Erythropoiesis in Older Men with Unexplained or Iron-Deficiency Anemia.J Clin Endocrinol Metab, vol. 105, no. 11, Nov. 2020, pp. 3396–403. Pubmed, doi:10.1210/clinem/dgaa521.
Artz AS, Stephens-Shields AJ, Bhasin S, Ellenberg SS, Cohen HJ, Snyder PJ. Markers of Iron Flux during Testosterone-Mediated Erythropoiesis in Older Men with Unexplained or Iron-Deficiency Anemia. J Clin Endocrinol Metab. 2020 Nov 1;105(11):3396–3403.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

November 1, 2020

Volume

105

Issue

11

Start / End Page

3396 / 3403

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Testosterone
  • Male
  • Hypogonadism
  • Humans
  • Hormone Replacement Therapy
  • Hemoglobins
  • Erythropoiesis
  • Endocrinology & Metabolism
  • Anemia, Iron-Deficiency