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Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC

Publication ,  Journal Article
Fast, OG; Gentry, B; Strouth, L; Niece, MB; Beckford, FA; Shell, SM
Published in: Bioscience Reports
July 31, 2019

Ruthenium organometallic compounds represent an attractive avenue in developing alternatives to platinum-based chemotherapeutic agents. While evidence has been presented indicating ruthenium-based compounds interact with isolated DNA in vitro, it is unclear what effect these compounds exert in cells. Moreover, the antibiotic efficacy of polynuclear ruthenium organometallic compounds remains uncertain. In the present study, we report that exposure to polynuclear ruthenium organometallic compounds induces recruitment of damaged DNA sensing protein Xeroderma pigmentosum Group C into chromatin-immobilized foci. Additionally, we observed one of the tested polynuclear ruthenium organometallic compounds displayed increased cytotoxicity against human cells deficient in nucleotide excision repair (NER). Taken together, these results suggest that polynuclear ruthenium organometallic compounds induce DNA damage in cells, and that cellular resistance to these compounds may be influenced by the NER DNA repair phenotype of the cells.

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Published In

Bioscience Reports

DOI

EISSN

1573-4935

ISSN

0144-8463

Publication Date

July 31, 2019

Volume

39

Issue

7

Publisher

Portland Press Ltd.

Related Subject Headings

  • Biochemistry & Molecular Biology
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
 

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Fast, O. G., Gentry, B., Strouth, L., Niece, M. B., Beckford, F. A., & Shell, S. M. (2019). Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC. Bioscience Reports, 39(7). https://doi.org/10.1042/bsr20190378
Fast, Olivia G., Brittany Gentry, Liah Strouth, Madison B. Niece, Floyd A. Beckford, and Steven M. Shell. “Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC.” Bioscience Reports 39, no. 7 (July 31, 2019). https://doi.org/10.1042/bsr20190378.
Fast OG, Gentry B, Strouth L, Niece MB, Beckford FA, Shell SM. Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC. Bioscience Reports. 2019 Jul 31;39(7).
Fast, Olivia G., et al. “Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC.” Bioscience Reports, vol. 39, no. 7, Portland Press Ltd., July 2019. Crossref, doi:10.1042/bsr20190378.
Fast OG, Gentry B, Strouth L, Niece MB, Beckford FA, Shell SM. Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC. Bioscience Reports. Portland Press Ltd.; 2019 Jul 31;39(7).

Published In

Bioscience Reports

DOI

EISSN

1573-4935

ISSN

0144-8463

Publication Date

July 31, 2019

Volume

39

Issue

7

Publisher

Portland Press Ltd.

Related Subject Headings

  • Biochemistry & Molecular Biology
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology