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Copper complexes containing thiosemicarbazones derived from 6-nitropiperonal: Antimicrobial and biophysical properties.

Publication ,  Journal Article
Beckford, FA; Webb, KR
Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
August 2017

A series of four thiosemicarbazones from 6-nitropiperonal along with the corresponding copper complexes were synthesized. The biophysical characteristics of the complexes were investigated by the binding to DNA and human serum albumin. The binding to DNA is moderate; the binding constants run from (0.49-7.50)×104M-1. In relation to HSA, the complexes interact strongly with binding constants on the order of 105M-1. The complexes also display antioxidant behavior as determined by the ability to scavenge diphenylpicrylhydrazyl (dpph) and nitric oxide radicals. The antimicrobial profiles of the compounds, tested against a panel of microbes including five of the ESKAPE pathogens (Staphylococcus aureus, MRSA, Escherichia coli, Klebsiella pneumoniae, MDR, Acinetobacter baumannii, Pseudomonas aeruginosa) and two yeasts (Candida albicans and Cryptococcus neoformans var. grubii), are also described. The compounds contain a core moiety that is similar to oxolinic acid, a quinolone antibiotic that targets DNA gyrase and topoisomerase (IV). The binding interaction between the complexes and these important antibacterial targets were studied by computational methods, chiefly docking studies. The calculated dissociation constants for the interaction with DNA gyrase B (from Staphylococcus aureus) range from 4.32 to 24.65μM; the binding was much stronger to topoisomerase IV, with dissociation constants ranging from 0.37 to 1.27μM.

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Published In

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

DOI

EISSN

1873-3557

ISSN

1386-1425

Publication Date

August 2017

Volume

183

Start / End Page

158 / 171

Related Subject Headings

  • Thiosemicarbazones
  • Protein Binding
  • Picrates
  • Molecular Docking Simulation
  • Copper
  • Coordination Complexes
  • Chemical Physics
  • Biphenyl Compounds
  • Benzaldehydes
  • Bacterial Proteins
 

Citation

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ICMJE
MLA
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Beckford, F. A., & Webb, K. R. (2017). Copper complexes containing thiosemicarbazones derived from 6-nitropiperonal: Antimicrobial and biophysical properties. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 183, 158–171. https://doi.org/10.1016/j.saa.2017.04.057
Beckford, Floyd A., and Kelsey R. Webb. “Copper complexes containing thiosemicarbazones derived from 6-nitropiperonal: Antimicrobial and biophysical properties.Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 183 (August 2017): 158–71. https://doi.org/10.1016/j.saa.2017.04.057.
Beckford FA, Webb KR. Copper complexes containing thiosemicarbazones derived from 6-nitropiperonal: Antimicrobial and biophysical properties. Spectrochimica acta Part A, Molecular and biomolecular spectroscopy. 2017 Aug;183:158–71.
Beckford, Floyd A., and Kelsey R. Webb. “Copper complexes containing thiosemicarbazones derived from 6-nitropiperonal: Antimicrobial and biophysical properties.Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, vol. 183, Aug. 2017, pp. 158–71. Epmc, doi:10.1016/j.saa.2017.04.057.
Beckford FA, Webb KR. Copper complexes containing thiosemicarbazones derived from 6-nitropiperonal: Antimicrobial and biophysical properties. Spectrochimica acta Part A, Molecular and biomolecular spectroscopy. 2017 Aug;183:158–171.
Journal cover image

Published In

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

DOI

EISSN

1873-3557

ISSN

1386-1425

Publication Date

August 2017

Volume

183

Start / End Page

158 / 171

Related Subject Headings

  • Thiosemicarbazones
  • Protein Binding
  • Picrates
  • Molecular Docking Simulation
  • Copper
  • Coordination Complexes
  • Chemical Physics
  • Biphenyl Compounds
  • Benzaldehydes
  • Bacterial Proteins