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Environmental and Aerosolized Severe Acute Respiratory Syndrome Coronavirus 2 Among Hospitalized Coronavirus Disease 2019 Patients.

Publication ,  Journal Article
Binder, RA; Alarja, NA; Robie, ER; Kochek, KE; Xiu, L; Rocha-Melogno, L; Abdelgadir, A; Goli, SV; Farrell, AS; Coleman, KK; Turner, AL ...
Published in: J Infect Dis
November 9, 2020

During April and May 2020, we studied 20 patients hospitalized with coronavirus disease 2019 (COVID-19), their hospital rooms (fomites and aerosols), and their close contacts for molecular and culture evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Among >400 samples, we found molecular evidence of virus in most sample types, especially the nasopharyngeal (NP), saliva, and fecal samples, but the prevalence of molecular positivity among fomites and aerosols was low. The agreement between NP swab and saliva positivity was high (89.5%; κ = 0.79). Two NP swabs collected from patients on days 1 and 7 post-symptom onset had evidence of infectious virus (2 passages over 14 days in Vero E6 cells). In summary, the low molecular prevalence and lack of viable SARS-CoV-2 virus in fomites and air samples implied low nosocomial risk of SARS-CoV-2 transmission through inanimate objects or aerosols.

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Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

November 9, 2020

Volume

222

Issue

11

Start / End Page

1798 / 1806

Location

United States

Related Subject Headings

  • Viral Load
  • Vero Cells
  • Saliva
  • SARS-CoV-2
  • Nasopharynx
  • Middle Aged
  • Microbiology
  • Male
  • Humans
  • Fomites
 

Citation

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Binder, R. A., Alarja, N. A., Robie, E. R., Kochek, K. E., Xiu, L., Rocha-Melogno, L., … Gray, G. C. (2020). Environmental and Aerosolized Severe Acute Respiratory Syndrome Coronavirus 2 Among Hospitalized Coronavirus Disease 2019 Patients. J Infect Dis, 222(11), 1798–1806. https://doi.org/10.1093/infdis/jiaa575
Binder, Raquel A., Natalie A. Alarja, Emily R. Robie, Kara E. Kochek, Leshan Xiu, Lucas Rocha-Melogno, Anfal Abdelgadir, et al. “Environmental and Aerosolized Severe Acute Respiratory Syndrome Coronavirus 2 Among Hospitalized Coronavirus Disease 2019 Patients.J Infect Dis 222, no. 11 (November 9, 2020): 1798–1806. https://doi.org/10.1093/infdis/jiaa575.
Binder RA, Alarja NA, Robie ER, Kochek KE, Xiu L, Rocha-Melogno L, et al. Environmental and Aerosolized Severe Acute Respiratory Syndrome Coronavirus 2 Among Hospitalized Coronavirus Disease 2019 Patients. J Infect Dis. 2020 Nov 9;222(11):1798–806.
Binder, Raquel A., et al. “Environmental and Aerosolized Severe Acute Respiratory Syndrome Coronavirus 2 Among Hospitalized Coronavirus Disease 2019 Patients.J Infect Dis, vol. 222, no. 11, Nov. 2020, pp. 1798–806. Pubmed, doi:10.1093/infdis/jiaa575.
Binder RA, Alarja NA, Robie ER, Kochek KE, Xiu L, Rocha-Melogno L, Abdelgadir A, Goli SV, Farrell AS, Coleman KK, Turner AL, Lautredou CC, Lednicky JA, Lee MJ, Polage CR, Simmons RA, Deshusses MA, Anderson BD, Gray GC. Environmental and Aerosolized Severe Acute Respiratory Syndrome Coronavirus 2 Among Hospitalized Coronavirus Disease 2019 Patients. J Infect Dis. 2020 Nov 9;222(11):1798–1806.
Journal cover image

Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

November 9, 2020

Volume

222

Issue

11

Start / End Page

1798 / 1806

Location

United States

Related Subject Headings

  • Viral Load
  • Vero Cells
  • Saliva
  • SARS-CoV-2
  • Nasopharynx
  • Middle Aged
  • Microbiology
  • Male
  • Humans
  • Fomites