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Developmental onset of enduring long-term potentiation in mouse hippocampus.

Publication ,  Journal Article
Ostrovskaya, OI; Cao, G; Eroglu, C; Harris, KM
Published in: Hippocampus
December 2020

Analysis of long-term potentiation (LTP) provides a powerful window into cellular mechanisms of learning and memory. Prior work shows late LTP (L-LTP), lasting >3 hr, occurs abruptly at postnatal day 12 (P12) in the stratum radiatum of rat hippocampal area CA1. The goal here was to determine the developmental profile of synaptic plasticity leading to L-LTP in the mouse hippocampus. Two mouse strains and two mutations known to affect synaptic plasticity were chosen: C57BL/6J and Fmr1-/y on the C57BL/6J background, and 129SVE and Hevin-/- (Sparcl1-/- ) on the 129SVE background. Like rats, hippocampal slices from all of the mice showed test pulse-induced depression early during development that was gradually resolved with maturation by 5 weeks. All the mouse strains showed a gradual progression between P10-P35 in the expression of short-term potentiation (STP), lasting ≤1 hr. In the 129SVE mice, L-LTP onset (>25% of slices) occurred by 3 weeks, reliable L-LTP (>50% slices) was achieved by 4 weeks, and Hevin-/- advanced this profile by 1 week. In the C57BL/6J mice, L-LTP onset occurred significantly later, over 3-4 weeks, and reliability was not achieved until 5 weeks. Although some of the Fmr1-/y mice showed L-LTP before 3 weeks, reliable L-LTP also was not achieved until 5 weeks. L-LTP onset was not advanced in any of the mouse genotypes by multiple bouts of theta-burst stimulation at 90 or 180 min intervals. These findings show important species differences in the onset of STP and L-LTP, which occur at the same age in rats but are sequentially acquired in mice.

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Published In

Hippocampus

DOI

EISSN

1098-1063

ISSN

1050-9631

Publication Date

December 2020

Volume

30

Issue

12

Start / End Page

1298 / 1312

Related Subject Headings

  • Species Specificity
  • Organ Culture Techniques
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Mice, Transgenic
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice, 129 Strain
  • Mice
  • Male
 

Citation

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Ostrovskaya, O. I., Cao, G., Eroglu, C., & Harris, K. M. (2020). Developmental onset of enduring long-term potentiation in mouse hippocampus. Hippocampus, 30(12), 1298–1312. https://doi.org/10.1002/hipo.23257
Ostrovskaya, Olga I., Guan Cao, Cagla Eroglu, and Kristen M. Harris. “Developmental onset of enduring long-term potentiation in mouse hippocampus.Hippocampus 30, no. 12 (December 2020): 1298–1312. https://doi.org/10.1002/hipo.23257.
Ostrovskaya OI, Cao G, Eroglu C, Harris KM. Developmental onset of enduring long-term potentiation in mouse hippocampus. Hippocampus. 2020 Dec;30(12):1298–312.
Ostrovskaya, Olga I., et al. “Developmental onset of enduring long-term potentiation in mouse hippocampus.Hippocampus, vol. 30, no. 12, Dec. 2020, pp. 1298–312. Epmc, doi:10.1002/hipo.23257.
Ostrovskaya OI, Cao G, Eroglu C, Harris KM. Developmental onset of enduring long-term potentiation in mouse hippocampus. Hippocampus. 2020 Dec;30(12):1298–1312.
Journal cover image

Published In

Hippocampus

DOI

EISSN

1098-1063

ISSN

1050-9631

Publication Date

December 2020

Volume

30

Issue

12

Start / End Page

1298 / 1312

Related Subject Headings

  • Species Specificity
  • Organ Culture Techniques
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Mice, Transgenic
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice, 129 Strain
  • Mice
  • Male