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Clinical trial discrimination of physical function instruments for psoriatic arthritis: A systematic review.

Publication ,  Journal Article
Leung, Y-Y; Holland, R; Mathew, AJ; Lindsay, C; Goel, N; Ogdie, A; Orbai, A-M; Hojgaard, P; Chau, J; Coates, LC; Strand, V; Gladman, DD ...
Published in: Semin Arthritis Rheum
October 2020

OBJECTIVES: Physical function (PF) is a core domain to be measured in randomized controlled trials (RCTs) of psoriatic arthritis (PsA), yet the discriminative performance of patient reported outcome measures (PROMs) for PF in RCTs has not been evaluated systematically. In this systematic review, we aimed to evaluate the clinical trial discrimination of PF-PROMs in PsA RCTs. METHODS: We searched PubMed and Scopus databases in English to identify all original RCTs on biological and targeted synthetic disease modifying anti-rheumatic drugs (DMARDs) conducted in PsA. We assessed quality in each article using the OMERACT good method checklist. Effect sizes (ES) for the PF-PROMs were calculated and appraised using a priori hypotheses. Evidence supporting clinical trial discrimination for each PF-PROM was summarized to derive recommendations. RESULTS: 35 articles from 31 RCTs were included. Four PF-PROMs had data for evaluation: HAQ-Disability Index (DI), HAQ-Spondyloarthritis (S), and Short Form 36-item Health Survey Physical Component Summary (SF-36 PCS) and Physical Functioning domain (SF-36 PF). As anticipated, higher ES values were observed for intervention groups than the control groups. Across all studies, for HAQ-DI, the median ES were -0.73 and -0.24 for intervention and control groups, respectively. Whereas for SF-36 PCS, the median ES were 0.77 and 0.23. For intervention and control groups, respectively. CONCLUSION: Clinical trial discrimination was supported for HAQ-DI and SF-36 PCS in PsA with low risk of bias; and for SF-36 PF and HAQ-S with some caution. More studies are required for HAQ-S.

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Published In

Semin Arthritis Rheum

DOI

EISSN

1532-866X

Publication Date

October 2020

Volume

50

Issue

5

Start / End Page

1158 / 1181

Location

United States

Related Subject Headings

  • Quality of Life
  • Patient Reported Outcome Measures
  • Humans
  • Arthritis, Psoriatic
  • Arthritis & Rheumatology
  • Antirheumatic Agents
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Leung, Y.-Y., Holland, R., Mathew, A. J., Lindsay, C., Goel, N., Ogdie, A., … Mease, P. (2020). Clinical trial discrimination of physical function instruments for psoriatic arthritis: A systematic review. Semin Arthritis Rheum, 50(5), 1158–1181. https://doi.org/10.1016/j.semarthrit.2020.05.022
Leung, Ying-Ying, Richard Holland, Ashish J. Mathew, Christine Lindsay, Niti Goel, Alexis Ogdie, Ana-Maria Orbai, et al. “Clinical trial discrimination of physical function instruments for psoriatic arthritis: A systematic review.Semin Arthritis Rheum 50, no. 5 (October 2020): 1158–81. https://doi.org/10.1016/j.semarthrit.2020.05.022.
Leung Y-Y, Holland R, Mathew AJ, Lindsay C, Goel N, Ogdie A, et al. Clinical trial discrimination of physical function instruments for psoriatic arthritis: A systematic review. Semin Arthritis Rheum. 2020 Oct;50(5):1158–81.
Leung, Ying-Ying, et al. “Clinical trial discrimination of physical function instruments for psoriatic arthritis: A systematic review.Semin Arthritis Rheum, vol. 50, no. 5, Oct. 2020, pp. 1158–81. Pubmed, doi:10.1016/j.semarthrit.2020.05.022.
Leung Y-Y, Holland R, Mathew AJ, Lindsay C, Goel N, Ogdie A, Orbai A-M, Hojgaard P, Chau J, Coates LC, Strand V, Gladman DD, Christensen R, Tillett W, Mease P. Clinical trial discrimination of physical function instruments for psoriatic arthritis: A systematic review. Semin Arthritis Rheum. 2020 Oct;50(5):1158–1181.
Journal cover image

Published In

Semin Arthritis Rheum

DOI

EISSN

1532-866X

Publication Date

October 2020

Volume

50

Issue

5

Start / End Page

1158 / 1181

Location

United States

Related Subject Headings

  • Quality of Life
  • Patient Reported Outcome Measures
  • Humans
  • Arthritis, Psoriatic
  • Arthritis & Rheumatology
  • Antirheumatic Agents
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences