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[Association between serum albumin and cognitive performance in elderly Chinese].

Publication ,  Journal Article
Yin, ZX; Wang, JL; Lyu, YB; Luo, JS; Zeng, Y; Shi, XM
Published in: Zhonghua Liu Xing Bing Xue Za Zhi
October 10, 2016

Objective: To explore association between serum albumin level and cognitive performance in elderly Chinese. Methods: All the subjects aged ≥65 years in the 8 longevity areas in Chinese longitudinal health longevity survey (CLHLS) were invited to participate the biomedical indepth CLHLS study, information about subjects' demographic characteristics, lifestyle, prevalence of diseases and health status was collected through household-interview. The cognitive performance was assessed with Mini Mental State Evaluation (MMSE) scale. Health examination was conducted by medical personnel and fasting venous blood samples were collected to detect the levels of triglycerides, total cholesterol, fasting glucose, creatine and blood albumin. MMSE score was compared and the trend was analyzed with generalized linear model. Association between albumin concentration and cognitive impairment was analyzed by logistic regression model. Results: Generalized linear model showed that adjusted MMSE score increased from 23.22 in the lowest quartile group to 25.07 in the highest quartile group (P for linear trend <0.001). Logistic regression analysis results showed that the higher albumin level was associated with the lower risk of cognitive impairment (P< 0.001), the OR decreased linearly with the increasing level of albumin (P<0.01), with the OR (95%CI) for the lower, higher and highest quartile groups was 0.64(0.45-0.91), 0.60(0.40-0.89) and 0.43(0.27-0.69), respectively, compared with the lowest quartile group. Conclusion: High level of serum albumin was associated with low risk of cognitive impairment.

Duke Scholars

Published In

Zhonghua Liu Xing Bing Xue Za Zhi

DOI

ISSN

0254-6450

Publication Date

October 10, 2016

Volume

37

Issue

10

Start / End Page

1323 / 1326

Location

China

Related Subject Headings

  • Triglycerides
  • Serum Albumin
  • Prevalence
  • Male
  • Longitudinal Studies
  • Longevity
  • Logistic Models
  • Linear Models
  • Humans
  • Health Surveys
 

Citation

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Yin, Z. X., Wang, J. L., Lyu, Y. B., Luo, J. S., Zeng, Y., & Shi, X. M. (2016). [Association between serum albumin and cognitive performance in elderly Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi, 37(10), 1323–1326. https://doi.org/10.3760/cma.j.issn.0254-6450.2016.10.001
Yin, Z. X., J. L. Wang, Y. B. Lyu, J. S. Luo, Y. Zeng, and X. M. Shi. “[Association between serum albumin and cognitive performance in elderly Chinese].Zhonghua Liu Xing Bing Xue Za Zhi 37, no. 10 (October 10, 2016): 1323–26. https://doi.org/10.3760/cma.j.issn.0254-6450.2016.10.001.
Yin ZX, Wang JL, Lyu YB, Luo JS, Zeng Y, Shi XM. [Association between serum albumin and cognitive performance in elderly Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi. 2016 Oct 10;37(10):1323–6.
Yin, Z. X., et al. “[Association between serum albumin and cognitive performance in elderly Chinese].Zhonghua Liu Xing Bing Xue Za Zhi, vol. 37, no. 10, Oct. 2016, pp. 1323–26. Pubmed, doi:10.3760/cma.j.issn.0254-6450.2016.10.001.
Yin ZX, Wang JL, Lyu YB, Luo JS, Zeng Y, Shi XM. [Association between serum albumin and cognitive performance in elderly Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi. 2016 Oct 10;37(10):1323–1326.

Published In

Zhonghua Liu Xing Bing Xue Za Zhi

DOI

ISSN

0254-6450

Publication Date

October 10, 2016

Volume

37

Issue

10

Start / End Page

1323 / 1326

Location

China

Related Subject Headings

  • Triglycerides
  • Serum Albumin
  • Prevalence
  • Male
  • Longitudinal Studies
  • Longevity
  • Logistic Models
  • Linear Models
  • Humans
  • Health Surveys