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Treatment of Neuromyelitis Optica: Review and Recommendations.

Publication ,  Journal Article
Kimbrough, DJ; Fujihara, K; Jacob, A; Lana-Peixoto, MA; Leite, MI; Levy, M; Marignier, R; Nakashima, I; Palace, J; de Seze, J; Stuve, O ...
Published in: Mult Scler Relat Disord
October 2012
Published version (DOI) Link to item

Neuromyelitis optica (NMO) is an autoimmune demyelinating disease preferentially targeting the optic nerves and spinal cord. Once regarded as a variant of multiple sclerosis (MS), NMO is now recognized to be a different disease with unique pathology and immunopathogenesis that does not respond to traditional MS immunomodulators such as interferons. Preventive therapy in NMO has focused on a range of immunosuppressive medications, none of which have been validated in a rigorous randomized trial. However, multiple retrospective and a few recent prospective studies have provided evidence for the use of six medications for the prevention of NMO exacerbations: azathioprine, rituximab, mycophenolate mofetil, prednisone, methotrexate and mitoxantrone. This review provides a comprehensive analysis of each of these medications in NMO and concludes with a set of recommended consensus practices.

Duke Scholars

Dorlan J Kimbrough
Author Dorlan J Kimbrough Neurology, MS & Neuroimmunology
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Published In

Mult Scler Relat Disord

DOI

10.1016/j.msard.2012.06.002

EISSN

2211-0356

Publication Date

October 2012

Volume

1

Issue

4

Start / End Page

180 / 187

Location

Netherlands

Related Subject Headings

  • 3209 Neurosciences
  • 1109 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
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Kimbrough, D. J., Fujihara, K., Jacob, A., Lana-Peixoto, M. A., Leite, M. I., Levy, M., … GJCF-CC&BR. (2012). Treatment of Neuromyelitis Optica: Review and Recommendations. Mult Scler Relat Disord, 1(4), 180–187. https://doi.org/10.1016/j.msard.2012.06.002
Kimbrough, Dorlan J., Kazuo Fujihara, Anu Jacob, Marco A. Lana-Peixoto, Maria Isabel Leite, Michael Levy, Romain Marignier, et al. “Treatment of Neuromyelitis Optica: Review and Recommendations.” Mult Scler Relat Disord 1, no. 4 (October 2012): 180–87. https://doi.org/10.1016/j.msard.2012.06.002.
Kimbrough DJ, Fujihara K, Jacob A, Lana-Peixoto MA, Leite MI, Levy M, et al. Treatment of Neuromyelitis Optica: Review and Recommendations. Mult Scler Relat Disord. 2012 Oct;1(4):180–7.
Kimbrough, Dorlan J., et al. “Treatment of Neuromyelitis Optica: Review and Recommendations.” Mult Scler Relat Disord, vol. 1, no. 4, Oct. 2012, pp. 180–87. Pubmed, doi:10.1016/j.msard.2012.06.002.
Kimbrough DJ, Fujihara K, Jacob A, Lana-Peixoto MA, Leite MI, Levy M, Marignier R, Nakashima I, Palace J, de Seze J, Stuve O, Tenembaum SN, Traboulsee A, Waubant E, Weinshenker BG, Wingerchuk DM, GJCF-CC&BR. Treatment of Neuromyelitis Optica: Review and Recommendations. Mult Scler Relat Disord. 2012 Oct;1(4):180–187.
Journal cover image

Published In

Mult Scler Relat Disord

DOI

10.1016/j.msard.2012.06.002

EISSN

2211-0356

Publication Date

October 2012

Volume

1

Issue

4

Start / End Page

180 / 187

Location

Netherlands

Related Subject Headings

  • 3209 Neurosciences
  • 1109 Neurosciences