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Case Series of Urrets-Zavalia Syndrome After Descemet Membrane Endothelial Keratoplasty.

Publication ,  Journal Article
Bhullar, PK; Venkateswaran, N; Kim, T
Published in: Cornea
May 1, 2021

PURPOSE: To present a case series of Urrets-Zavalia syndrome (UZS) that developed after Descemet membrane endothelial keratoplasty (DMEK). METHODS: A retrospective chart review was performed to identify patients who underwent DMEK by a single surgeon at the Duke Eye Center from 2017 to 2019 and subsequently developed UZS. Demographic data, preoperative history, operative notes, and postoperative course were reviewed. RESULTS: We describe 5 cases of UZS after DMEK (ages 19-74 years; 3 men and 2 women). Onset of UZS was noted at postoperative week 1 (n = 1), 2 (n =3), or 4 (n = 1). Four patients had an underlying diagnosis of Fuchs endothelial dystrophy and 1 had posterior polymorphous corneal dystrophy. Sixty percent (n = 3) of patients had an elevated intraocular pressure on postoperative day 0 or 1, and 40% (n = 2) of patients also had a pupillary block. One patient developed UZS after a rebubbling procedure for partial graft detachment and another developed UZS after repeat DMEK transplantation. Of the 3 patients who underwent bilateral combined DMEK and cataract surgery, 1 developed UZS in the second eye, whereas 2 developed UZS in the first eye. Most patients experienced monocular diplopia or had cosmetic concerns because of their mydriatic pupils. Two patients had spontaneous improvement in mydriasis. CONCLUSIONS: UZS after DMEK is rare, with only 2 cases in the literature: Holtmann et al and Isac et al. We present the largest case series of UZS after DMEK to date. Postoperative elevation in intraocular pressure is a common contributing factor. Evaluation of more patients may elucidate additional risk factors for this condition.

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Published In

Cornea

DOI

EISSN

1536-4798

Publication Date

May 1, 2021

Volume

40

Issue

5

Start / End Page

652 / 655

Location

United States

Related Subject Headings

  • Young Adult
  • Tissue Adhesions
  • Retrospective Studies
  • Pupil Disorders
  • Postoperative Complications
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Iris
  • Intraocular Pressure
 

Citation

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Bhullar, P. K., Venkateswaran, N., & Kim, T. (2021). Case Series of Urrets-Zavalia Syndrome After Descemet Membrane Endothelial Keratoplasty. Cornea, 40(5), 652–655. https://doi.org/10.1097/ICO.0000000000002514
Bhullar, Paramjit K., Nandini Venkateswaran, and Terry Kim. “Case Series of Urrets-Zavalia Syndrome After Descemet Membrane Endothelial Keratoplasty.Cornea 40, no. 5 (May 1, 2021): 652–55. https://doi.org/10.1097/ICO.0000000000002514.
Bhullar PK, Venkateswaran N, Kim T. Case Series of Urrets-Zavalia Syndrome After Descemet Membrane Endothelial Keratoplasty. Cornea. 2021 May 1;40(5):652–5.
Bhullar, Paramjit K., et al. “Case Series of Urrets-Zavalia Syndrome After Descemet Membrane Endothelial Keratoplasty.Cornea, vol. 40, no. 5, May 2021, pp. 652–55. Pubmed, doi:10.1097/ICO.0000000000002514.
Bhullar PK, Venkateswaran N, Kim T. Case Series of Urrets-Zavalia Syndrome After Descemet Membrane Endothelial Keratoplasty. Cornea. 2021 May 1;40(5):652–655.

Published In

Cornea

DOI

EISSN

1536-4798

Publication Date

May 1, 2021

Volume

40

Issue

5

Start / End Page

652 / 655

Location

United States

Related Subject Headings

  • Young Adult
  • Tissue Adhesions
  • Retrospective Studies
  • Pupil Disorders
  • Postoperative Complications
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Iris
  • Intraocular Pressure