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New Therapeutics for Hepatitis B: The Road to Cure.

Publication ,  Journal Article
Naggie, S; Lok, AS
Published in: Annu Rev Med
January 27, 2021

Chronic hepatitis B virus (HBV) infection impacts an estimated 257-291 million people globally. The current approach to treatment for chronic HBV infection is complex, reflecting a risk:benefit approach driven by the lack of an effective curative regimen. This complexity and the lack of a durable treatment response, necessitating indefinite treatment in the majority of cases, have resulted in low uptake of testing and treatment, particularly in regions where comprehensive primary care is lacking and access to affordable testing and treatment is limited. Multiple targeted therapies are now in early human study with the primary goal to achieve persistent HBV DNA and hepatitis B surface antigen suppression after a finite course of treatment, which is referred to as functional cure. This article summarizes the current therapies for HBV infection and discusses the limitations of these therapies, novel approaches to HBV cure, and therapeutic endpoints of clinical trials aimed to cure hepatitis B.

Duke Scholars

Published In

Annu Rev Med

DOI

EISSN

1545-326X

Publication Date

January 27, 2021

Volume

72

Start / End Page

93 / 105

Location

United States

Related Subject Headings

  • Humans
  • Hepatitis B, Chronic
  • General & Internal Medicine
  • Disease Management
  • Antiviral Agents
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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ICMJE
MLA
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Naggie, S., & Lok, A. S. (2021). New Therapeutics for Hepatitis B: The Road to Cure. Annu Rev Med, 72, 93–105. https://doi.org/10.1146/annurev-med-080119-103356
Naggie, Susanna, and Anna S. Lok. “New Therapeutics for Hepatitis B: The Road to Cure.Annu Rev Med 72 (January 27, 2021): 93–105. https://doi.org/10.1146/annurev-med-080119-103356.
Naggie S, Lok AS. New Therapeutics for Hepatitis B: The Road to Cure. Annu Rev Med. 2021 Jan 27;72:93–105.
Naggie, Susanna, and Anna S. Lok. “New Therapeutics for Hepatitis B: The Road to Cure.Annu Rev Med, vol. 72, Jan. 2021, pp. 93–105. Pubmed, doi:10.1146/annurev-med-080119-103356.
Naggie S, Lok AS. New Therapeutics for Hepatitis B: The Road to Cure. Annu Rev Med. 2021 Jan 27;72:93–105.

Published In

Annu Rev Med

DOI

EISSN

1545-326X

Publication Date

January 27, 2021

Volume

72

Start / End Page

93 / 105

Location

United States

Related Subject Headings

  • Humans
  • Hepatitis B, Chronic
  • General & Internal Medicine
  • Disease Management
  • Antiviral Agents
  • 3202 Clinical sciences
  • 1103 Clinical Sciences