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Gut microbial molecules in behavioural and neurodegenerative conditions.

Publication ,  Journal Article
Needham, BD; Kaddurah-Daouk, R; Mazmanian, SK
Published in: Nat Rev Neurosci
December 2020

Mounting evidence suggests that the gut microbiome impacts brain development and function. Gut-brain connections may be mediated by an assortment of microbial molecules that are produced in the gastrointestinal tract, which can subsequently permeate many organs, including sometimes the brain. Studies in animal models have identified molecular cues propagated from intestinal bacteria to the brain that can affect neurological function and/or neurodevelopmental and neurodegenerative conditions. Herein, we describe bacterial metabolites with known or suspected neuromodulatory activity, define mechanisms of signalling pathways from the gut microbiota to the brain and discuss direct effects that gut bacterial molecules are likely exerting on specific brain cells. Many discoveries are recent, and the findings described in this Perspective are largely novel and yet to be extensively validated. However, expanding research into the dynamic molecular communications between gut microorganisms and the CNS continues to uncover critical and previously unappreciated clues in understanding the pathophysiology of behavioural, psychiatric and neurodegenerative diseases.

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Published In

Nat Rev Neurosci

DOI

EISSN

1471-0048

Publication Date

December 2020

Volume

21

Issue

12

Start / End Page

717 / 731

Location

England

Related Subject Headings

  • Neurology & Neurosurgery
  • Neurodegenerative Diseases
  • Mental Disorders
  • Humans
  • Gastrointestinal Microbiome
  • Brain
  • Bacteria
  • Animals
  • 5202 Biological psychology
  • 3209 Neurosciences
 

Citation

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Needham, B. D., Kaddurah-Daouk, R., & Mazmanian, S. K. (2020). Gut microbial molecules in behavioural and neurodegenerative conditions. Nat Rev Neurosci, 21(12), 717–731. https://doi.org/10.1038/s41583-020-00381-0
Needham, Brittany D., Rima Kaddurah-Daouk, and Sarkis K. Mazmanian. “Gut microbial molecules in behavioural and neurodegenerative conditions.Nat Rev Neurosci 21, no. 12 (December 2020): 717–31. https://doi.org/10.1038/s41583-020-00381-0.
Needham BD, Kaddurah-Daouk R, Mazmanian SK. Gut microbial molecules in behavioural and neurodegenerative conditions. Nat Rev Neurosci. 2020 Dec;21(12):717–31.
Needham, Brittany D., et al. “Gut microbial molecules in behavioural and neurodegenerative conditions.Nat Rev Neurosci, vol. 21, no. 12, Dec. 2020, pp. 717–31. Pubmed, doi:10.1038/s41583-020-00381-0.
Needham BD, Kaddurah-Daouk R, Mazmanian SK. Gut microbial molecules in behavioural and neurodegenerative conditions. Nat Rev Neurosci. 2020 Dec;21(12):717–731.

Published In

Nat Rev Neurosci

DOI

EISSN

1471-0048

Publication Date

December 2020

Volume

21

Issue

12

Start / End Page

717 / 731

Location

England

Related Subject Headings

  • Neurology & Neurosurgery
  • Neurodegenerative Diseases
  • Mental Disorders
  • Humans
  • Gastrointestinal Microbiome
  • Brain
  • Bacteria
  • Animals
  • 5202 Biological psychology
  • 3209 Neurosciences