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Patient-reported symptom severity, interference with daily activities, and adverse events in older and younger women receiving chemotherapy for early breast cancer.

Publication ,  Journal Article
Nyrop, KA; Deal, AM; Chen, YT; Reeve, BB; Basch, EM; Wood, WA; Shachar, SS; Carey, LA; Reeder-Hayes, KE; Dees, EC; Jolly, TA; Kimmick, GG ...
Published in: Cancer
March 2021

To the authors' knowledge, it is unknown whether patient-reported symptom severity and symptom interference with daily activities differ between younger (aged <65 years) and older (aged ≥65 years) women receiving similar chemotherapy regimens for early breast cancer (EBC).Study participants rated 17 side effects of chemotherapy regimens currently in use in clinical practice (2014-2019).Of 284 women with EBC (stage I-III), approximately 57% were aged <65 years and 43% were aged ≥65 years. For anthracycline-based regimens, a higher percentage of younger women reported moderate, severe, or very severe (MSVS) hot flashes (49% vs 18%) (P < .001). For nonanthracycline regimens, a higher percentage of younger women reported MSVS hot flashes (38% vs 19%) (P = .009) and a lower percentage reported MSVS arthralgia (28% vs 49%) (P = .005). With regard to symptom interference with daily activities, a higher percentage of younger women being treated with anthracycline-based regimens reported MSVS hot flashes (32% vs 7%) (P = .001) and myalgia (38% vs 18%) (P = .02). For nonanthracycline chemotherapy, a higher percentage of younger women reported MSVS interference for hot flashes (26% vs 9%) (P = .006) and lower percentages reported abdominal pain (13% vs 28%) (P = .02). Overall, there were no significant differences noted among younger versus older patients with regard to hospitalizations (19% vs 12%; P = .19), dose reductions (34% vs 31%; P = .50), dose delays (22% vs 25%; P = .59), or early treatment discontinuation (16% vs 16%; P = .9546).Older and younger women with EBC who were treated with identical chemotherapy regimens generally experienced similar levels of symptom severity, symptom-related interference with daily activities, and adverse events.In this study, women receiving chemotherapy for early breast cancer rated the severity of 17 symptoms and symptom interference with their activities of daily living. Older (aged ≥65 years) and younger (aged <65 years) women who received identical chemotherapy regimens generally experienced similar levels of symptom severity, symptom-related interference with daily activities, and adverse events.

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Published In

Cancer

DOI

EISSN

1097-0142

ISSN

0008-543X

Publication Date

March 2021

Volume

127

Issue

6

Start / End Page

957 / 967

Related Subject Headings

  • Severity of Illness Index
  • Patient Reported Outcome Measures
  • Oncology & Carcinogenesis
  • Middle Aged
  • Humans
  • Female
  • Breast Neoplasms
  • Aged
  • Age Factors
  • Adult
 

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Nyrop, K. A., Deal, A. M., Chen, Y. T., Reeve, B. B., Basch, E. M., Wood, W. A., … Muss, H. B. (2021). Patient-reported symptom severity, interference with daily activities, and adverse events in older and younger women receiving chemotherapy for early breast cancer. Cancer, 127(6), 957–967. https://doi.org/10.1002/cncr.33329
Nyrop, Kirsten A., Allison M. Deal, Yi Tang Chen, Bryce B. Reeve, Ethan M. Basch, William A. Wood, Shlomit S. Shachar, et al. “Patient-reported symptom severity, interference with daily activities, and adverse events in older and younger women receiving chemotherapy for early breast cancer.Cancer 127, no. 6 (March 2021): 957–67. https://doi.org/10.1002/cncr.33329.
Nyrop, Kirsten A., et al. “Patient-reported symptom severity, interference with daily activities, and adverse events in older and younger women receiving chemotherapy for early breast cancer.Cancer, vol. 127, no. 6, Mar. 2021, pp. 957–67. Epmc, doi:10.1002/cncr.33329.
Nyrop KA, Deal AM, Chen YT, Reeve BB, Basch EM, Wood WA, Shachar SS, Carey LA, Reeder-Hayes KE, Dees EC, Jolly TA, Kimmick GG, Karuturi MS, Reinbolt RE, Speca JC, Lee JT, Brenizer A, Muss HB. Patient-reported symptom severity, interference with daily activities, and adverse events in older and younger women receiving chemotherapy for early breast cancer. Cancer. 2021 Mar;127(6):957–967.
Journal cover image

Published In

Cancer

DOI

EISSN

1097-0142

ISSN

0008-543X

Publication Date

March 2021

Volume

127

Issue

6

Start / End Page

957 / 967

Related Subject Headings

  • Severity of Illness Index
  • Patient Reported Outcome Measures
  • Oncology & Carcinogenesis
  • Middle Aged
  • Humans
  • Female
  • Breast Neoplasms
  • Aged
  • Age Factors
  • Adult