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Conserved principles of transcriptional networks controlling metabolic flexibility in archaea.

Publication ,  Journal Article
Schmid, AK
Published in: Emerging topics in life sciences
December 2018

Gene regulation is intimately connected with metabolism, enabling the appropriate timing and tuning of biochemical pathways to substrate availability. In microorganisms, such as archaea and bacteria, transcription factors (TFs) often directly sense external cues such as nutrient substrates, metabolic intermediates, or redox status to regulate gene expression. Intense recent interest has characterized the functions of a large number of such regulatory TFs in archaea, which regulate a diverse array of unique archaeal metabolic capabilities. However, it remains unclear how the co-ordinated activity of the interconnected metabolic and transcription networks produces the dynamic flexibility so frequently observed in archaeal cells as they respond to energy limitation and intermittent substrate availability. In this review, we communicate the current state of the art regarding these archaeal networks and their dynamic properties. We compare the topology of these archaeal networks to those known for bacteria to highlight conserved and unique aspects. We present a new computational model for an exemplar archaeal network, aiming to lay the groundwork toward understanding general principles that unify the dynamic function of integrated metabolic-transcription networks across archaea and bacteria.

Duke Scholars

Published In

Emerging topics in life sciences

DOI

EISSN

2397-8562

ISSN

2397-8554

Publication Date

December 2018

Volume

2

Issue

4

Start / End Page

659 / 669

Related Subject Headings

  • 41 Environmental sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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MLA
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Schmid, A. K. (2018). Conserved principles of transcriptional networks controlling metabolic flexibility in archaea. Emerging Topics in Life Sciences, 2(4), 659–669. https://doi.org/10.1042/etls20180036
Schmid, Amy K. “Conserved principles of transcriptional networks controlling metabolic flexibility in archaea.Emerging Topics in Life Sciences 2, no. 4 (December 2018): 659–69. https://doi.org/10.1042/etls20180036.
Schmid AK. Conserved principles of transcriptional networks controlling metabolic flexibility in archaea. Emerging topics in life sciences. 2018 Dec;2(4):659–69.
Schmid, Amy K. “Conserved principles of transcriptional networks controlling metabolic flexibility in archaea.Emerging Topics in Life Sciences, vol. 2, no. 4, Dec. 2018, pp. 659–69. Epmc, doi:10.1042/etls20180036.
Schmid AK. Conserved principles of transcriptional networks controlling metabolic flexibility in archaea. Emerging topics in life sciences. 2018 Dec;2(4):659–669.

Published In

Emerging topics in life sciences

DOI

EISSN

2397-8562

ISSN

2397-8554

Publication Date

December 2018

Volume

2

Issue

4

Start / End Page

659 / 669

Related Subject Headings

  • 41 Environmental sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences