Skip to main content

Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion.

Publication ,  Journal Article
Lei, V; Petty, AJ; Atwater, AR; Wolfe, SA; MacLeod, AS
Published in: Front Immunol
2020

The skin is an active immune organ that functions as the first and largest site of defense to the outside environment. Serving as the primary interface between host and pathogen, the skin's early immune responses to viral invaders often determine the course and severity of infection. We review the current literature pertaining to the mechanisms of cutaneous viral invasion for classical skin-tropic, oncogenic, and vector-borne skin viruses. We discuss the skin's evolved mechanisms for innate immune viral defense against these invading pathogens, as well as unique strategies utilized by the viruses to escape immune detection. We additionally explore the roles that demographic and environmental factors, such as age, biological sex, and the cutaneous microbiome, play in altering the host immune response to viral threats.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Front Immunol

DOI

EISSN

1664-3224

Publication Date

2020

Volume

11

Start / End Page

593901

Location

Switzerland

Related Subject Headings

  • Viruses
  • Virus Physiological Phenomena
  • Virus Diseases
  • Viral Tropism
  • Risk Factors
  • Immunity, Innate
  • Immune Evasion
  • Humans
  • Host-Pathogen Interactions
  • Environment
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lei, V., Petty, A. J., Atwater, A. R., Wolfe, S. A., & MacLeod, A. S. (2020). Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion. Front Immunol, 11, 593901. https://doi.org/10.3389/fimmu.2020.593901
Lei, Vivian, Amy J. Petty, Amber R. Atwater, Sarah A. Wolfe, and Amanda S. MacLeod. “Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion.Front Immunol 11 (2020): 593901. https://doi.org/10.3389/fimmu.2020.593901.
Lei V, Petty AJ, Atwater AR, Wolfe SA, MacLeod AS. Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion. Front Immunol. 2020;11:593901.
Lei, Vivian, et al. “Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion.Front Immunol, vol. 11, 2020, p. 593901. Pubmed, doi:10.3389/fimmu.2020.593901.
Lei V, Petty AJ, Atwater AR, Wolfe SA, MacLeod AS. Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion. Front Immunol. 2020;11:593901.

Published In

Front Immunol

DOI

EISSN

1664-3224

Publication Date

2020

Volume

11

Start / End Page

593901

Location

Switzerland

Related Subject Headings

  • Viruses
  • Virus Physiological Phenomena
  • Virus Diseases
  • Viral Tropism
  • Risk Factors
  • Immunity, Innate
  • Immune Evasion
  • Humans
  • Host-Pathogen Interactions
  • Environment