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Consanguinity Rates Predict Long Runs of Homozygosity in Jewish Populations.

Publication ,  Journal Article
Kang, JTL; Goldberg, A; Edge, MD; Behar, DM; Rosenberg, NA
Published in: Human heredity
January 2016

Recent studies have highlighted the potential of analyses of genomic sharing to produce insight into the demographic processes affecting human populations. We study runs of homozygosity (ROH) in 18 Jewish populations, examining these groups in relation to 123 non-Jewish populations sampled worldwide.By sorting ROH into 3 length classes (short, intermediate, and long), we evaluate the impact of demographic processes on genomic patterns in Jewish populations.We find that the portion of the genome appearing in long ROH - the length class most directly related to recent consanguinity - closely accords with data gathered from interviews during the 1950s on frequencies of consanguineous unions in various Jewish groups.The high correlation between 1950s consanguinity levels and coverage by long ROH explains differences across populations in ROH patterns. The dissection of ROH into length classes and the comparison to consanguinity data assist in understanding a number of additional phenomena, including similarities of Jewish populations to Middle Eastern, European, and Central and South Asian non-Jewish populations in short ROH patterns, relative lengths of identity-by-descent tracts in different Jewish groups, and the "population isolate" status of the Ashkenazi Jews.

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Published In

Human heredity

DOI

EISSN

1423-0062

ISSN

0001-5652

Publication Date

January 2016

Volume

82

Issue

3-4

Start / End Page

87 / 102

Related Subject Headings

  • Genetics & Heredity
  • 3105 Genetics
  • 0604 Genetics
 

Citation

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Kang, J. T. L., Goldberg, A., Edge, M. D., Behar, D. M., & Rosenberg, N. A. (2016). Consanguinity Rates Predict Long Runs of Homozygosity in Jewish Populations. Human Heredity, 82(3–4), 87–102. https://doi.org/10.1159/000478897
Kang, Jonathan T. L., Amy Goldberg, Michael D. Edge, Doron M. Behar, and Noah A. Rosenberg. “Consanguinity Rates Predict Long Runs of Homozygosity in Jewish Populations.Human Heredity 82, no. 3–4 (January 2016): 87–102. https://doi.org/10.1159/000478897.
Kang JTL, Goldberg A, Edge MD, Behar DM, Rosenberg NA. Consanguinity Rates Predict Long Runs of Homozygosity in Jewish Populations. Human heredity. 2016 Jan;82(3–4):87–102.
Kang, Jonathan T. L., et al. “Consanguinity Rates Predict Long Runs of Homozygosity in Jewish Populations.Human Heredity, vol. 82, no. 3–4, Jan. 2016, pp. 87–102. Epmc, doi:10.1159/000478897.
Kang JTL, Goldberg A, Edge MD, Behar DM, Rosenberg NA. Consanguinity Rates Predict Long Runs of Homozygosity in Jewish Populations. Human heredity. 2016 Jan;82(3–4):87–102.
Journal cover image

Published In

Human heredity

DOI

EISSN

1423-0062

ISSN

0001-5652

Publication Date

January 2016

Volume

82

Issue

3-4

Start / End Page

87 / 102

Related Subject Headings

  • Genetics & Heredity
  • 3105 Genetics
  • 0604 Genetics