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Ferroptosis of epithelial ovarian cancer: genetic determinants and therapeutic potential.

Publication ,  Journal Article
Lin, C-C; Chi, J-T
Published in: Oncotarget
September 2020

Epithelial ovarian cancer (OVCA) is the most lethal gynecologic cancer. Current treatment for OVCA involves surgical debulking of the tumors followed by combination chemotherapies. While most patients achieve complete remission, many OVCA will recur and develop chemo-resistance. Whereas recurrent OVCA may be treated by angiogenesis inhibitors, PARP inhibitors, or immunotherapies, the clinical outcomes of recurrence OVCA are still unsatisfactory. One new promising anti-tumor strategy is ferroptosis, a novel form of regulated cell death featured by lipid peroxidation. In this review, we have summarized several recent studies on the ferroptosis of OVCA. Also, we summarize our current understanding of various genetic determinants of ferroptosis and their underlying mechanisms in OVCA. Furthermore, ferroptosis can be combined with other standard cancer therapeutics, which has shown synergistic effects. Therefore, such a combination of therapeutics could lead to new therapeutic strategies to improve the response rate and overcome resistance. By understanding the genetic determinants and underlying mechanisms, ferroptosis may have significant therapeutic potential to improve the clinical outcome of women with OVCA.

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Published In

Oncotarget

DOI

EISSN

1949-2553

ISSN

1949-2553

Publication Date

September 2020

Volume

11

Issue

39

Start / End Page

3562 / 3570

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
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Lin, C.-C., & Chi, J.-T. (2020). Ferroptosis of epithelial ovarian cancer: genetic determinants and therapeutic potential. Oncotarget, 11(39), 3562–3570. https://doi.org/10.18632/oncotarget.27749
Lin, Chao-Chieh, and Jen-Tsan Chi. “Ferroptosis of epithelial ovarian cancer: genetic determinants and therapeutic potential.Oncotarget 11, no. 39 (September 2020): 3562–70. https://doi.org/10.18632/oncotarget.27749.
Lin, Chao-Chieh, and Jen-Tsan Chi. “Ferroptosis of epithelial ovarian cancer: genetic determinants and therapeutic potential.Oncotarget, vol. 11, no. 39, Sept. 2020, pp. 3562–70. Epmc, doi:10.18632/oncotarget.27749.

Published In

Oncotarget

DOI

EISSN

1949-2553

ISSN

1949-2553

Publication Date

September 2020

Volume

11

Issue

39

Start / End Page

3562 / 3570

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis