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The Utility of Novel Renal Biomarkers in Assessment of Chronic Kidney Disease of Unknown Etiology (CKDu): A Review.

Publication ,  Journal Article
Gunasekara, TDKSC; De Silva, PMCS; Herath, C; Siribaddana, S; Siribaddana, N; Jayasumana, C; Jayasinghe, S; Cardenas-Gonzalez, M; Jayasundara, N
Published in: International journal of environmental research and public health
December 2020

Chronic Kidney Disease (CKD) is a globally prevalent non-communicable disease with significant mortality and morbidity. It is typically associated with diabetes and hypertension; however, over the last two decades, an emergence of CKD of unknown etiology (CKDu) has claimed thousands of lives in several tropical agricultural communities. CKDu is associated with gradual loss of renal function without initial symptoms until reaching complete kidney failure and eventually death. The most impacted are young adult males of lower socio-economic strata. Since the disease progression can be successfully attenuated through early detection, the development of superior screening and management measures is of utmost importance. In contrast to the conventional biomarkers, novel biomarkers with improved sensitivity and specificity are being discussed as promising tools for early diagnosis of the disease. This review summarizes emerging novel biomarkers used in assessing CKD and discusses the current utility and diagnostic potential of such biomarkers for CKDu screening in clinical settings of different communities impacted by CKDu. Our goal is to provide a framework for practitioners in CKDu impacted regions to consider the use of these novel biomarkers through this synthesis. The increased use of these biomarkers will not only help to validate their diagnostic power further and establish potential prognostic value but may also provide critical insights into sites and mechanisms of renal damage.

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Published In

International journal of environmental research and public health

DOI

EISSN

1660-4601

ISSN

1661-7827

Publication Date

December 2020

Volume

17

Issue

24

Start / End Page

E9522

Related Subject Headings

  • Toxicology
  • Sri Lanka
  • Sensitivity and Specificity
  • Renal Insufficiency, Chronic
  • Male
  • Kidney
  • Humans
  • Biomarkers
 

Citation

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Gunasekara, T. D. K. S. C., De Silva, P. M. C. S., Herath, C., Siribaddana, S., Siribaddana, N., Jayasumana, C., … Jayasundara, N. (2020). The Utility of Novel Renal Biomarkers in Assessment of Chronic Kidney Disease of Unknown Etiology (CKDu): A Review. International Journal of Environmental Research and Public Health, 17(24), E9522. https://doi.org/10.3390/ijerph17249522
Gunasekara, T. D. K. S. C., P Mangala C. S. De Silva, Chula Herath, Sisira Siribaddana, Nipuna Siribaddana, Channa Jayasumana, Sudheera Jayasinghe, Maria Cardenas-Gonzalez, and Nishad Jayasundara. “The Utility of Novel Renal Biomarkers in Assessment of Chronic Kidney Disease of Unknown Etiology (CKDu): A Review.International Journal of Environmental Research and Public Health 17, no. 24 (December 2020): E9522. https://doi.org/10.3390/ijerph17249522.
Gunasekara TDKSC, De Silva PMCS, Herath C, Siribaddana S, Siribaddana N, Jayasumana C, et al. The Utility of Novel Renal Biomarkers in Assessment of Chronic Kidney Disease of Unknown Etiology (CKDu): A Review. International journal of environmental research and public health. 2020 Dec;17(24):E9522.
Gunasekara, T. D. K. S. C., et al. “The Utility of Novel Renal Biomarkers in Assessment of Chronic Kidney Disease of Unknown Etiology (CKDu): A Review.International Journal of Environmental Research and Public Health, vol. 17, no. 24, Dec. 2020, p. E9522. Epmc, doi:10.3390/ijerph17249522.
Gunasekara TDKSC, De Silva PMCS, Herath C, Siribaddana S, Siribaddana N, Jayasumana C, Jayasinghe S, Cardenas-Gonzalez M, Jayasundara N. The Utility of Novel Renal Biomarkers in Assessment of Chronic Kidney Disease of Unknown Etiology (CKDu): A Review. International journal of environmental research and public health. 2020 Dec;17(24):E9522.

Published In

International journal of environmental research and public health

DOI

EISSN

1660-4601

ISSN

1661-7827

Publication Date

December 2020

Volume

17

Issue

24

Start / End Page

E9522

Related Subject Headings

  • Toxicology
  • Sri Lanka
  • Sensitivity and Specificity
  • Renal Insufficiency, Chronic
  • Male
  • Kidney
  • Humans
  • Biomarkers