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Recent advances in the research and management of sepsis-associated DIC.

Publication ,  Journal Article
Iba, T; Connors, JM; Nagaoka, I; Levy, JH
Published in: Int J Hematol
January 2021

Disseminated intravascular coagulation (DIC) is a common and life-threatening complication in sepsis. Sepsis-associated DIC is recognized as the systemic activation in coagulation with suppressed fibrinolysis that leads to organ dysfunction in combination with systemic intravascular inflammation. In this process, thrombin contributes a key role in connecting both coagulation and inflammation. Endothelial injury, a result of sepsis, causes DIC due to the effect of multiple activated factors that include neutrophils, platelets, and damage-associated molecular patterns. Recent advances in the understanding of pathophysiology have made it possible to diagnose sepsis-associated DIC at earlier timing with better accuracy. However, progress in the treatment is still limited, and new therapeutics for sepsis-associated DIC are needed.

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Published In

Int J Hematol

DOI

EISSN

1865-3774

Publication Date

January 2021

Volume

113

Issue

1

Start / End Page

24 / 33

Location

Japan

Related Subject Headings

  • Thrombin
  • Sepsis
  • Prognosis
  • Neutrophils
  • Inflammation
  • Immunology
  • Humans
  • Fibrinolysis
  • Endothelial Cells
  • Early Diagnosis
 

Citation

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Iba, T., Connors, J. M., Nagaoka, I., & Levy, J. H. (2021). Recent advances in the research and management of sepsis-associated DIC. Int J Hematol, 113(1), 24–33. https://doi.org/10.1007/s12185-020-03053-y
Iba, Toshiaki, Jean Marie Connors, Isao Nagaoka, and Jerrold H. Levy. “Recent advances in the research and management of sepsis-associated DIC.Int J Hematol 113, no. 1 (January 2021): 24–33. https://doi.org/10.1007/s12185-020-03053-y.
Iba T, Connors JM, Nagaoka I, Levy JH. Recent advances in the research and management of sepsis-associated DIC. Int J Hematol. 2021 Jan;113(1):24–33.
Iba, Toshiaki, et al. “Recent advances in the research and management of sepsis-associated DIC.Int J Hematol, vol. 113, no. 1, Jan. 2021, pp. 24–33. Pubmed, doi:10.1007/s12185-020-03053-y.
Iba T, Connors JM, Nagaoka I, Levy JH. Recent advances in the research and management of sepsis-associated DIC. Int J Hematol. 2021 Jan;113(1):24–33.
Journal cover image

Published In

Int J Hematol

DOI

EISSN

1865-3774

Publication Date

January 2021

Volume

113

Issue

1

Start / End Page

24 / 33

Location

Japan

Related Subject Headings

  • Thrombin
  • Sepsis
  • Prognosis
  • Neutrophils
  • Inflammation
  • Immunology
  • Humans
  • Fibrinolysis
  • Endothelial Cells
  • Early Diagnosis