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Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.

Publication ,  Journal Article
Daly, MB; Pal, T; Berry, MP; Buys, SS; Dickson, P; Domchek, SM; Elkhanany, A; Friedman, S; Goggins, M; Hutton, ML; CGC, ; Karlan, BY; Khan, S ...
Published in: J Natl Compr Canc Netw
January 6, 2021

The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic focus primarily on assessment of pathogenic or likely pathogenic variants associated with increased risk of breast, ovarian, and pancreatic cancer and recommended approaches to genetic testing/counseling and management strategies in individuals with these pathogenic or likely pathogenic variants. This manuscript focuses on cancer risk and risk management for BRCA-related breast/ovarian cancer syndrome and Li-Fraumeni syndrome. Carriers of a BRCA1/2 pathogenic or likely pathogenic variant have an excessive risk for both breast and ovarian cancer that warrants consideration of more intensive screening and preventive strategies. There is also evidence that risks of prostate cancer and pancreatic cancer are elevated in these carriers. Li-Fraumeni syndrome is a highly penetrant cancer syndrome associated with a high lifetime risk for cancer, including soft tissue sarcomas, osteosarcomas, premenopausal breast cancer, colon cancer, gastric cancer, adrenocortical carcinoma, and brain tumors.

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Published In

J Natl Compr Canc Netw

DOI

EISSN

1540-1413

Publication Date

January 6, 2021

Volume

19

Issue

1

Start / End Page

77 / 102

Location

United States

Related Subject Headings

  • Pancreatic Neoplasms
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Mutation
  • Male
  • Humans
  • Genetic Testing
  • Genetic Predisposition to Disease
  • Genetic Counseling
  • Genes, BRCA2
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Daly, M. B., Pal, T., Berry, M. P., Buys, S. S., Dickson, P., Domchek, S. M., … Dwyer, M. A. (2021). Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw, 19(1), 77–102. https://doi.org/10.6004/jnccn.2021.0001
Daly, Mary B., Tuya Pal, Michael P. Berry, Saundra S. Buys, Patricia Dickson, Susan M. Domchek, Ahmed Elkhanany, et al. “Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.J Natl Compr Canc Netw 19, no. 1 (January 6, 2021): 77–102. https://doi.org/10.6004/jnccn.2021.0001.
Daly MB, Pal T, Berry MP, Buys SS, Dickson P, Domchek SM, et al. Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2021 Jan 6;19(1):77–102.
Daly, Mary B., et al. “Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.J Natl Compr Canc Netw, vol. 19, no. 1, Jan. 2021, pp. 77–102. Pubmed, doi:10.6004/jnccn.2021.0001.
Daly MB, Pal T, Berry MP, Buys SS, Dickson P, Domchek SM, Elkhanany A, Friedman S, Goggins M, Hutton ML, CGC, Karlan BY, Khan S, Klein C, Kohlmann W, Kurian AW, Laronga C, Litton JK, Mak JS, LCGC, Menendez CS, Merajver SD, Norquist BS, Offit K, Pederson HJ, Reiser G, Senter-Jamieson L, Shannon KM, Shatsky R, Visvanathan K, Weitzel JN, Wick MJ, Wisinski KB, Yurgelun MB, Darlow SD, Dwyer MA. Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2021 Jan 6;19(1):77–102.

Published In

J Natl Compr Canc Netw

DOI

EISSN

1540-1413

Publication Date

January 6, 2021

Volume

19

Issue

1

Start / End Page

77 / 102

Location

United States

Related Subject Headings

  • Pancreatic Neoplasms
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Mutation
  • Male
  • Humans
  • Genetic Testing
  • Genetic Predisposition to Disease
  • Genetic Counseling
  • Genes, BRCA2