Multiorgan Dysfunction After Severe Traumatic Brain Injury: Epidemiology, Mechanisms, and Clinical Management.
Publication
, Journal Article
Krishnamoorthy, V; Komisarow, JM; Laskowitz, DT; Vavilala, MS
Published in: Chest
September 2021
Traumatic brain injury (TBI) is a major global health problem and a major contributor to morbidity and mortality following multisystem trauma. Extracranial organ dysfunction is common after severe TBI and significantly impacts clinical care and outcomes following injury. Despite this, extracranial organ dysfunction remains an understudied topic compared with organ dysfunction in other critical care paradigms. In this review, we will: 1) summarize the epidemiology of extracranial multiorgan dysfunction following severe TBI; 2) examine relevant mechanisms that may be involved in the development of multi-organ dysfunction following severe TBI; and 3) discuss clinical management strategies to care for these complex patients.
Duke Scholars
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Published In
Chest
DOI
EISSN
1931-3543
ISSN
0012-3692
Publication Date
September 2021
Volume
160
Issue
3
Start / End Page
956 / 964
Related Subject Headings
- Trauma Severity Indices
- Respiratory System
- Multiple Organ Failure
- Humans
- Critical Care
- Brain Injuries, Traumatic
- 3202 Clinical sciences
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Krishnamoorthy, V., Komisarow, J. M., Laskowitz, D. T., & Vavilala, M. S. (2021). Multiorgan Dysfunction After Severe Traumatic Brain Injury: Epidemiology, Mechanisms, and Clinical Management. Chest, 160(3), 956–964. https://doi.org/10.1016/j.chest.2021.01.016
Krishnamoorthy, Vijay, Jordan M. Komisarow, Daniel T. Laskowitz, and Monica S. Vavilala. “Multiorgan Dysfunction After Severe Traumatic Brain Injury: Epidemiology, Mechanisms, and Clinical Management.” Chest 160, no. 3 (September 2021): 956–64. https://doi.org/10.1016/j.chest.2021.01.016.
Krishnamoorthy V, Komisarow JM, Laskowitz DT, Vavilala MS. Multiorgan Dysfunction After Severe Traumatic Brain Injury: Epidemiology, Mechanisms, and Clinical Management. Chest. 2021 Sep;160(3):956–64.
Krishnamoorthy, Vijay, et al. “Multiorgan Dysfunction After Severe Traumatic Brain Injury: Epidemiology, Mechanisms, and Clinical Management.” Chest, vol. 160, no. 3, Sept. 2021, pp. 956–64. Epmc, doi:10.1016/j.chest.2021.01.016.
Krishnamoorthy V, Komisarow JM, Laskowitz DT, Vavilala MS. Multiorgan Dysfunction After Severe Traumatic Brain Injury: Epidemiology, Mechanisms, and Clinical Management. Chest. 2021 Sep;160(3):956–964.
Published In
Chest
DOI
EISSN
1931-3543
ISSN
0012-3692
Publication Date
September 2021
Volume
160
Issue
3
Start / End Page
956 / 964
Related Subject Headings
- Trauma Severity Indices
- Respiratory System
- Multiple Organ Failure
- Humans
- Critical Care
- Brain Injuries, Traumatic
- 3202 Clinical sciences
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences