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Uncovering the Harms of Treating Clostridioides difficile Colonization.

Publication ,  Journal Article
Polage, CR; Turner, NA
Published in: mSphere
January 13, 2021

Patients with toxin-negative Clostridioides difficile-positive diarrhea are often treated with oral vancomycin with the assumption that treatment is more beneficial than harmful. However, this hypothesis has never been formally tested, and recent studies suggest that most such patients recover quickly without treatment and can be colonized rather than infected. Fishbein et al. conducted a prospective, placebo-controlled randomized trial to systematically evaluate the effects, risks, and benefits of oral vancomycin in these patients (S. R. S. Fishbein, T. Hink, K. A. Reske, C. Cass, et al., mSphere 6:e00936-20, 2020, https://doi.org/10.1128/mSphere.00936-20). Although small, the results are intriguing and suggest the adverse antibiotic-induced effects of vancomycin outweigh the clinical benefit when colonization is more likely than disease.

Duke Scholars

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Published In

mSphere

DOI

EISSN

2379-5042

Publication Date

January 13, 2021

Volume

6

Issue

1

Location

United States

Related Subject Headings

  • Vancomycin
  • Prospective Studies
  • Humans
  • Diarrhea
  • Clostridioides difficile
  • Clostridioides
 

Citation

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Polage, C. R., & Turner, N. A. (2021). Uncovering the Harms of Treating Clostridioides difficile Colonization. MSphere, 6(1). https://doi.org/10.1128/mSphere.01296-20
Polage, Christopher R., and Nicholas A. Turner. “Uncovering the Harms of Treating Clostridioides difficile Colonization.MSphere 6, no. 1 (January 13, 2021). https://doi.org/10.1128/mSphere.01296-20.
Polage CR, Turner NA. Uncovering the Harms of Treating Clostridioides difficile Colonization. mSphere. 2021 Jan 13;6(1).
Polage, Christopher R., and Nicholas A. Turner. “Uncovering the Harms of Treating Clostridioides difficile Colonization.MSphere, vol. 6, no. 1, Jan. 2021. Pubmed, doi:10.1128/mSphere.01296-20.
Polage CR, Turner NA. Uncovering the Harms of Treating Clostridioides difficile Colonization. mSphere. 2021 Jan 13;6(1).

Published In

mSphere

DOI

EISSN

2379-5042

Publication Date

January 13, 2021

Volume

6

Issue

1

Location

United States

Related Subject Headings

  • Vancomycin
  • Prospective Studies
  • Humans
  • Diarrhea
  • Clostridioides difficile
  • Clostridioides