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First- and second-degree family history of ovarian and breast cancer in relation to risk of invasive ovarian cancer in African American and white women.

Publication ,  Journal Article
Bethea, TN; Ochs-Balcom, HM; Bandera, EV; Beeghly-Fadiel, A; Camacho, F; Chyn, D; Cloyd, EK; Harris, HR; Joslin, CE; Myers, E; Moorman, PG ...
Published in: Int J Cancer
June 15, 2021

Family history (FH) of ovarian cancer and breast cancer are well-established risk factors for ovarian cancer, but few studies have examined this association in African American (AA) and white women by histotype. We assessed first- and second-degree FH of ovarian and breast cancer and risk of epithelial ovarian cancer in the Ovarian Cancer in Women of African Ancestry Consortium. Analyses included 1052 AA cases, 2328 AA controls, 2380 white cases and 3982 white controls. Race-specific odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multilevel logistic regression with adjustment for covariates. Analyses were stratified by histotype (high-grade serous vs others). First-degree FH of ovarian cancer was associated with high-grade serous carcinoma in AA (OR = 2.32, 95% CI: 1.50, 3.59) and white women (OR = 2.48, 95% CI: 1.82, 3.38). First-degree FH of breast cancer increased risk irrespective of histotype in AAs, but with high-grade serous carcinoma only in white women. Associations with second-degree FH of ovarian cancer were observed for overall ovarian cancer in white women and with high-grade serous carcinoma in both groups. First-degree FH of ovarian cancer and of breast cancer, and second-degree FH of ovarian cancer is strongly associated with high-grade serous ovarian carcinoma in AA and white women. The association of FH of breast cancer with high-grade serous ovarian carcinoma is similar in white women and AA women, but may differ for other histotypes.

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Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

June 15, 2021

Volume

148

Issue

12

Start / End Page

2964 / 2973

Location

United States

Related Subject Headings

  • White People
  • United States
  • Prevalence
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Neoplasm Grading
  • Middle Aged
  • Medical History Taking
  • Humans
  • Hereditary Breast and Ovarian Cancer Syndrome
 

Citation

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Bethea, T. N., Ochs-Balcom, H. M., Bandera, E. V., Beeghly-Fadiel, A., Camacho, F., Chyn, D., … Schildkraut, J. M. (2021). First- and second-degree family history of ovarian and breast cancer in relation to risk of invasive ovarian cancer in African American and white women. Int J Cancer, 148(12), 2964–2973. https://doi.org/10.1002/ijc.33493
Bethea, Traci N., Heather M. Ochs-Balcom, Elisa V. Bandera, Alicia Beeghly-Fadiel, Fabian Camacho, Deanna Chyn, Emily K. Cloyd, et al. “First- and second-degree family history of ovarian and breast cancer in relation to risk of invasive ovarian cancer in African American and white women.Int J Cancer 148, no. 12 (June 15, 2021): 2964–73. https://doi.org/10.1002/ijc.33493.
Bethea TN, Ochs-Balcom HM, Bandera EV, Beeghly-Fadiel A, Camacho F, Chyn D, et al. First- and second-degree family history of ovarian and breast cancer in relation to risk of invasive ovarian cancer in African American and white women. Int J Cancer. 2021 Jun 15;148(12):2964–73.
Bethea, Traci N., et al. “First- and second-degree family history of ovarian and breast cancer in relation to risk of invasive ovarian cancer in African American and white women.Int J Cancer, vol. 148, no. 12, June 2021, pp. 2964–73. Pubmed, doi:10.1002/ijc.33493.
Bethea TN, Ochs-Balcom HM, Bandera EV, Beeghly-Fadiel A, Camacho F, Chyn D, Cloyd EK, Harris HR, Joslin CE, Myers E, Moorman PG, Peres LC, Rosenow W, Setiawan VW, Wu AH, Rosenberg L, Schildkraut JM. First- and second-degree family history of ovarian and breast cancer in relation to risk of invasive ovarian cancer in African American and white women. Int J Cancer. 2021 Jun 15;148(12):2964–2973.
Journal cover image

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

June 15, 2021

Volume

148

Issue

12

Start / End Page

2964 / 2973

Location

United States

Related Subject Headings

  • White People
  • United States
  • Prevalence
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Neoplasm Grading
  • Middle Aged
  • Medical History Taking
  • Humans
  • Hereditary Breast and Ovarian Cancer Syndrome