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Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement.

Publication ,  Journal Article
Narayanasamy, S; Nation, RL; Mahony, AA; Grayson, ML; Kwong, JC; Sherry, NL; Khumra, S; Ellis, AG; Frauman, AG; Holmes, NE
Published in: Open forum infectious diseases
January 2021

We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring was used to maximize probability of efficacy and minimize potential for toxicity.

Duke Scholars

Published In

Open forum infectious diseases

DOI

EISSN

2328-8957

ISSN

2328-8957

Publication Date

January 2021

Volume

8

Issue

1

Start / End Page

ofaa572

Related Subject Headings

  • 3207 Medical microbiology
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Narayanasamy, S., Nation, R. L., Mahony, A. A., Grayson, M. L., Kwong, J. C., Sherry, N. L., … Holmes, N. E. (2021). Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement. Open Forum Infectious Diseases, 8(1), ofaa572. https://doi.org/10.1093/ofid/ofaa572
Narayanasamy, Shanti, Roger L. Nation, Andrew A. Mahony, M Lindsay Grayson, Jason C. Kwong, Norelle L. Sherry, Sharmila Khumra, Andrew G. Ellis, Albert G. Frauman, and Natasha E. Holmes. “Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement.Open Forum Infectious Diseases 8, no. 1 (January 2021): ofaa572. https://doi.org/10.1093/ofid/ofaa572.
Narayanasamy S, Nation RL, Mahony AA, Grayson ML, Kwong JC, Sherry NL, et al. Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement. Open forum infectious diseases. 2021 Jan;8(1):ofaa572.
Narayanasamy, Shanti, et al. “Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement.Open Forum Infectious Diseases, vol. 8, no. 1, Jan. 2021, p. ofaa572. Epmc, doi:10.1093/ofid/ofaa572.
Narayanasamy S, Nation RL, Mahony AA, Grayson ML, Kwong JC, Sherry NL, Khumra S, Ellis AG, Frauman AG, Holmes NE. Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement. Open forum infectious diseases. 2021 Jan;8(1):ofaa572.
Journal cover image

Published In

Open forum infectious diseases

DOI

EISSN

2328-8957

ISSN

2328-8957

Publication Date

January 2021

Volume

8

Issue

1

Start / End Page

ofaa572

Related Subject Headings

  • 3207 Medical microbiology
  • 3202 Clinical sciences