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Contact dermatitis associated with preservatives: Retrospective analysis of North American Contact Dermatitis Group data, 1994 through 2016.

Publication ,  Journal Article
Atwater, AR; Petty, AJ; Liu, B; Green, CL; Silverberg, JI; DeKoven, JG; Belsito, DV; Reeder, MJ; Sasseville, D; Taylor, JS; Maibach, HI ...
Published in: J Am Acad Dermatol
April 2021

BACKGROUND: Preservatives are often necessary components of commercial products. Large-scale North American studies on preservative allergy are limited. OBJECTIVE: To evaluate demographics, positive patch test reactions (PPTRs), clinical relevance, and trends for preservatives tested by the North American Contact Dermatitis Group. METHODS: We conducted a retrospective cross-sectional analysis of North American Contact Dermatitis Group patch testing results of preservatives from 1994 through 2016. RESULTS: A total of 50,799 patients were tested; 11,338 (22.3%) had a PPTR to at least 1 preservative. The most frequent reactions were to methylisothiazolinone 0.2% aqueous (aq) (12.2%), formaldehyde 2% aq (7.8%), formaldehyde 1% aq (7.8%), quaternium-15 2% petrolatum (pet) (7.7%), and methyldibromo glutaronitrile/phenoxyethanol 2% pet (5.1%). Paraben mix 12% pet (1%), iodopropynyl butylcarbamate 0.1% pet (0.4%), benzyl alcohol 1% pet (0.3%), and phenoxyethanol 1% pet (0.2%) had the lowest PPTRs. Linear regression analysis of preservatives tested showed that only methylchloroisothiazolinone/methylisothiazolinone 0.01% aq (parameter estimate, 0.42; 95% CI, 0.17-0.66; P < .005) had a significant increase in PPTRs over time. LIMITATIONS: Collected variables are dependent on clinical judgment. Results may be prone to referral selection bias. CONCLUSIONS: This large North American study provides insight on preservative PPTRs and trends from 1994 through 2016.

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Published In

J Am Acad Dermatol

DOI

EISSN

1097-6787

Publication Date

April 2021

Volume

84

Issue

4

Start / End Page

965 / 976

Location

United States

Related Subject Headings

  • United States
  • Sex Distribution
  • Retrospective Studies
  • Preservatives, Pharmaceutical
  • Patch Tests
  • Organ Specificity
  • Middle Aged
  • Male
  • Linear Models
  • Hypersensitivity, Immediate
 

Citation

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Atwater, A. R., Petty, A. J., Liu, B., Green, C. L., Silverberg, J. I., DeKoven, J. G., … Warshaw, E. M. (2021). Contact dermatitis associated with preservatives: Retrospective analysis of North American Contact Dermatitis Group data, 1994 through 2016. J Am Acad Dermatol, 84(4), 965–976. https://doi.org/10.1016/j.jaad.2020.07.059
Atwater, Amber Reck, Amy J. Petty, Beiyu Liu, Cynthia L. Green, Jonathan I. Silverberg, Joel G. DeKoven, Donald V. Belsito, et al. “Contact dermatitis associated with preservatives: Retrospective analysis of North American Contact Dermatitis Group data, 1994 through 2016.J Am Acad Dermatol 84, no. 4 (April 2021): 965–76. https://doi.org/10.1016/j.jaad.2020.07.059.
Atwater AR, Petty AJ, Liu B, Green CL, Silverberg JI, DeKoven JG, et al. Contact dermatitis associated with preservatives: Retrospective analysis of North American Contact Dermatitis Group data, 1994 through 2016. J Am Acad Dermatol. 2021 Apr;84(4):965–76.
Atwater, Amber Reck, et al. “Contact dermatitis associated with preservatives: Retrospective analysis of North American Contact Dermatitis Group data, 1994 through 2016.J Am Acad Dermatol, vol. 84, no. 4, Apr. 2021, pp. 965–76. Pubmed, doi:10.1016/j.jaad.2020.07.059.
Atwater AR, Petty AJ, Liu B, Green CL, Silverberg JI, DeKoven JG, Belsito DV, Reeder MJ, Sasseville D, Taylor JS, Maibach HI, Zirwas MJ, Marks JG, Zug KA, Fowler JF, Pratt MD, DeLeo VA, Warshaw EM. Contact dermatitis associated with preservatives: Retrospective analysis of North American Contact Dermatitis Group data, 1994 through 2016. J Am Acad Dermatol. 2021 Apr;84(4):965–976.
Journal cover image

Published In

J Am Acad Dermatol

DOI

EISSN

1097-6787

Publication Date

April 2021

Volume

84

Issue

4

Start / End Page

965 / 976

Location

United States

Related Subject Headings

  • United States
  • Sex Distribution
  • Retrospective Studies
  • Preservatives, Pharmaceutical
  • Patch Tests
  • Organ Specificity
  • Middle Aged
  • Male
  • Linear Models
  • Hypersensitivity, Immediate