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Chordoma of the sacrum and mobile spine: a narrative review.

Publication ,  Journal Article
Pennington, Z; Ehresman, J; McCarthy, EF; Ahmed, AK; Pittman, PD; Lubelski, D; Goodwin, CR; Sciubba, DM
Published in: Spine J
March 2021

Chordoma is a notochord-derived primary tumor of the skull base and vertebral column known to affect 0.08 to 0.5 per 100,000 persons worldwide. Patients commonly present with mechanical, midline pain with or without radicular features secondary to nerve root compression. Management of these lesions has classically revolved around oncologic resection, defined by en bloc resection of the lesion with negative margins as this was found to significantly improve both local control and overall survival. With advancement in radiation modalities, namely the increased availability of focused photon therapy and proton beam radiation, high-dose (>50 Gy) neoadjuvant or adjuvant radiotherapy is also becoming a standard of care. At present chemotherapy does not appear to have a role, but ongoing investigations into the ontogeny and molecular pathophysiology of chordoma promise to identify therapeutic targets that may further alter this paradigm. In this narrative review we describe the epidemiology, histopathology, diagnosis, and treatment of chordoma.

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Published In

Spine J

DOI

EISSN

1878-1632

Publication Date

March 2021

Volume

21

Issue

3

Start / End Page

500 / 517

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Spinal Neoplasms
  • Sacrum
  • Orthopedics
  • Neoplasm Recurrence, Local
  • Humans
  • Chordoma
  • 4201 Allied health and rehabilitation science
  • 3202 Clinical sciences
  • 1109 Neurosciences
 

Citation

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ICMJE
MLA
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Pennington, Z., Ehresman, J., McCarthy, E. F., Ahmed, A. K., Pittman, P. D., Lubelski, D., … Sciubba, D. M. (2021). Chordoma of the sacrum and mobile spine: a narrative review. Spine J, 21(3), 500–517. https://doi.org/10.1016/j.spinee.2020.10.009
Pennington, Zach, Jeff Ehresman, Edward F. McCarthy, A Karim Ahmed, Patricia D. Pittman, Daniel Lubelski, C Rory Goodwin, and Daniel M. Sciubba. “Chordoma of the sacrum and mobile spine: a narrative review.Spine J 21, no. 3 (March 2021): 500–517. https://doi.org/10.1016/j.spinee.2020.10.009.
Pennington Z, Ehresman J, McCarthy EF, Ahmed AK, Pittman PD, Lubelski D, et al. Chordoma of the sacrum and mobile spine: a narrative review. Spine J. 2021 Mar;21(3):500–17.
Pennington, Zach, et al. “Chordoma of the sacrum and mobile spine: a narrative review.Spine J, vol. 21, no. 3, Mar. 2021, pp. 500–17. Pubmed, doi:10.1016/j.spinee.2020.10.009.
Pennington Z, Ehresman J, McCarthy EF, Ahmed AK, Pittman PD, Lubelski D, Goodwin CR, Sciubba DM. Chordoma of the sacrum and mobile spine: a narrative review. Spine J. 2021 Mar;21(3):500–517.
Journal cover image

Published In

Spine J

DOI

EISSN

1878-1632

Publication Date

March 2021

Volume

21

Issue

3

Start / End Page

500 / 517

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Spinal Neoplasms
  • Sacrum
  • Orthopedics
  • Neoplasm Recurrence, Local
  • Humans
  • Chordoma
  • 4201 Allied health and rehabilitation science
  • 3202 Clinical sciences
  • 1109 Neurosciences