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Simulation based evaluation of a fan beam coded aperture x-ray diffraction imaging system for biospecimen analysis.

Publication ,  Journal Article
Stryker, S; Kapadia, AJ; Greenberg, JA
Published in: Physics in medicine and biology
March 2021

X-ray diffraction (XRD) imaging yields spatially resolved, material-specific information, which can aid medical diagnosis and inform treatment. In this work we used simulations to analyze the utility of fan beam coded aperture XRD imaging for fast, high-resolution scatter imaging of biospecimens for tissue assessment. To evaluate the proposed system's utility in a specific task, we employed a deterministic model to produce simulated data from biologically realistic breast tissue phantoms and model-based reconstruction to recover a spatial map of the XRD signatures throughout the phantoms. We found an XRD spatial resolution of ≈1 mm with a mean reconstructed spectral accuracy of 0.98 ± 0.01 for a simulated 1 × 150 mm2 fan beam operating at 160 kVp, 10 mA, and 4.5 s exposures. A classifier for cancer detection was developed utilizing cross-correlation of XRD spectra against a spectral library, with a receiver operating characteristic curve with an area under the curve value of 0.972. Our results indicated a potential diagnostic modality that could aid in tasks ranging from analysis of ex-vivo pathology biospecimens to intraoperative cancer margin assessment, motivating future work to develop an experimental system while enabling the development of improved algorithms for imaging and tissue analysis-based classification performance.

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Published In

Physics in medicine and biology

DOI

EISSN

1361-6560

ISSN

0031-9155

Publication Date

March 2021

Volume

66

Issue

6

Start / End Page

065022

Related Subject Headings

  • X-Ray Diffraction
  • Scattering, Radiation
  • Reproducibility of Results
  • ROC Curve
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Humans
  • Female
  • Computer Simulation
  • Breast Neoplasms
 

Citation

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Stryker, S., Kapadia, A. J., & Greenberg, J. A. (2021). Simulation based evaluation of a fan beam coded aperture x-ray diffraction imaging system for biospecimen analysis. Physics in Medicine and Biology, 66(6), 065022. https://doi.org/10.1088/1361-6560/abe779
Stryker, Stefan, Anuj J. Kapadia, and Joel A. Greenberg. “Simulation based evaluation of a fan beam coded aperture x-ray diffraction imaging system for biospecimen analysis.Physics in Medicine and Biology 66, no. 6 (March 2021): 065022. https://doi.org/10.1088/1361-6560/abe779.
Stryker S, Kapadia AJ, Greenberg JA. Simulation based evaluation of a fan beam coded aperture x-ray diffraction imaging system for biospecimen analysis. Physics in medicine and biology. 2021 Mar;66(6):065022.
Stryker, Stefan, et al. “Simulation based evaluation of a fan beam coded aperture x-ray diffraction imaging system for biospecimen analysis.Physics in Medicine and Biology, vol. 66, no. 6, Mar. 2021, p. 065022. Epmc, doi:10.1088/1361-6560/abe779.
Stryker S, Kapadia AJ, Greenberg JA. Simulation based evaluation of a fan beam coded aperture x-ray diffraction imaging system for biospecimen analysis. Physics in medicine and biology. 2021 Mar;66(6):065022.
Journal cover image

Published In

Physics in medicine and biology

DOI

EISSN

1361-6560

ISSN

0031-9155

Publication Date

March 2021

Volume

66

Issue

6

Start / End Page

065022

Related Subject Headings

  • X-Ray Diffraction
  • Scattering, Radiation
  • Reproducibility of Results
  • ROC Curve
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Humans
  • Female
  • Computer Simulation
  • Breast Neoplasms