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Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial.

Publication ,  Journal Article
Adams-Chapman, I; Watterberg, KL; Nolen, TL; Hirsch, S; Cole, CA; Cotten, CM; Oh, W; Poindexter, BB; Zaterka-Baxter, KM; Das, A; Lacy, CB ...
Published in: J Perinatol
August 2021

OBJECTIVE: This study evaluates the 24-month follow-up for the NICHD Neonatal Research Network (NRN) Inositol for Retinopathy Trial. STUDY DESIGN: Bayley Scales of Infants Development-III and a standardized neurosensory examination were performed in infants enrolled in the main trial. Moderate/severe NDI was defined as BSID-III Cognitive or Motor composite score <85, moderate or severe cerebral palsy, blindness, or hearing loss that prevents communication despite amplification were assessed. RESULTS: Primary outcome was determined for 605/638 (95%). The mean gestational age was 25.8 ± 1.3 weeks and mean birthweight was 805 ± 192 g. Treatment group did not affect the risk for the composite outcome of death or survival with moderate/severe NDI (60% vs 56%, p = 0.40). CONCLUSIONS: Treatment group did not affect the risk of death or survival with moderate/severe NDI. Despite early termination, this study represents the largest RCT of extremely preterm infants treated with myo-inositol with neurodevelopmental outcome data.

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Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

August 2021

Volume

41

Issue

8

Start / End Page

2072 / 2087

Location

United States

Related Subject Headings

  • Pediatrics
  • Inositol
  • Infant, Newborn
  • Infant, Extremely Premature
  • Humans
  • Gestational Age
  • Child Development
  • Cerebral Palsy
  • 3213 Paediatrics
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

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Adams-Chapman, I., Watterberg, K. L., Nolen, T. L., Hirsch, S., Cole, C. A., Cotten, C. M., … Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, . (2021). Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial. J Perinatol, 41(8), 2072–2087. https://doi.org/10.1038/s41372-021-01018-5
Adams-Chapman, Ira, Kristi L. Watterberg, Tracy L. Nolen, Shawn Hirsch, Carol A. Cole, C Michael Cotten, William Oh, et al. “Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial.J Perinatol 41, no. 8 (August 2021): 2072–87. https://doi.org/10.1038/s41372-021-01018-5.
Adams-Chapman I, Watterberg KL, Nolen TL, Hirsch S, Cole CA, Cotten CM, et al. Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial. J Perinatol. 2021 Aug;41(8):2072–87.
Adams-Chapman, Ira, et al. “Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial.J Perinatol, vol. 41, no. 8, Aug. 2021, pp. 2072–87. Pubmed, doi:10.1038/s41372-021-01018-5.
Adams-Chapman I, Watterberg KL, Nolen TL, Hirsch S, Cole CA, Cotten CM, Oh W, Poindexter BB, Zaterka-Baxter KM, Das A, Lacy CB, Scorsone AM, Duncan AF, DeMauro SB, Goldstein RF, Colaizy TT, Wilson-Costello DE, Purdy IB, Hintz SR, Heyne RJ, Myers GJ, Fuller J, Merhar S, Harmon HM, Peralta-Carcelen M, Kilbride HW, Maitre NL, Vohr BR, Natarajan G, Mintz-Hittner H, Quinn GE, Wallace DK, Olson RJ, Orge FH, Tsui I, Gaynon M, Hutchinson AK, He Y-G, Winter TW, Yang MB, Haider KM, Cogen MS, Hug D, Bremer DL, Donahue JP, Lucas WR, Phelps DL, Higgins RD, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial. J Perinatol. 2021 Aug;41(8):2072–2087.

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

August 2021

Volume

41

Issue

8

Start / End Page

2072 / 2087

Location

United States

Related Subject Headings

  • Pediatrics
  • Inositol
  • Infant, Newborn
  • Infant, Extremely Premature
  • Humans
  • Gestational Age
  • Child Development
  • Cerebral Palsy
  • 3213 Paediatrics
  • 1114 Paediatrics and Reproductive Medicine