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Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity.

Publication ,  Journal Article
Lee, CQE; Kerouanton, B; Chothani, S; Zhang, S; Chen, Y; Mantri, CK; Hock, DH; Lim, R; Nadkarni, R; Huynh, VT; Lim, D; Chew, WL; Zhong, FL ...
Published in: Nat Commun
April 9, 2021

Mito-SEPs are small open reading frame-encoded peptides that localize to the mitochondria to regulate metabolism. Motivated by an intriguing negative association between mito-SEPs and inflammation, here we screen for mito-SEPs that modify inflammatory outcomes and report a mito-SEP named "Modulator of cytochrome C oxidase during Inflammation" (MOCCI) that is upregulated during inflammation and infection to promote host-protective resolution. MOCCI, a paralog of the NDUFA4 subunit of cytochrome C oxidase (Complex IV), replaces NDUFA4 in Complex IV during inflammation to lower mitochondrial membrane potential and reduce ROS production, leading to cyto-protection and dampened immune response. The MOCCI transcript also generates miR-147b, which targets the NDUFA4 mRNA with similar immune dampening effects as MOCCI, but simultaneously enhances RIG-I/MDA-5-mediated viral immunity. Our work uncovers a dual-component pleiotropic regulation of host inflammation and immunity by MOCCI (C15ORF48) for safeguarding the host during infection and inflammation.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

April 9, 2021

Volume

12

Issue

1

Start / End Page

2130

Location

England

Related Subject Headings

  • Up-Regulation
  • Reactive Oxygen Species
  • Primary Cell Culture
  • Nuclear Proteins
  • Neoplasm Proteins
  • Mitochondria
  • MicroRNAs
  • Membrane Potential, Mitochondrial
  • Inflammation
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Lee, C. Q. E., Kerouanton, B., Chothani, S., Zhang, S., Chen, Y., Mantri, C. K., … Ho, L. (2021). Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity. Nat Commun, 12(1), 2130. https://doi.org/10.1038/s41467-021-22397-5
Lee, Cheryl Q. E., Baptiste Kerouanton, Sonia Chothani, Shan Zhang, Ying Chen, Chinmay Kumar Mantri, Daniella Helena Hock, et al. “Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity.Nat Commun 12, no. 1 (April 9, 2021): 2130. https://doi.org/10.1038/s41467-021-22397-5.
Lee CQE, Kerouanton B, Chothani S, Zhang S, Chen Y, Mantri CK, et al. Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity. Nat Commun. 2021 Apr 9;12(1):2130.
Lee, Cheryl Q. E., et al. “Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity.Nat Commun, vol. 12, no. 1, Apr. 2021, p. 2130. Pubmed, doi:10.1038/s41467-021-22397-5.
Lee CQE, Kerouanton B, Chothani S, Zhang S, Chen Y, Mantri CK, Hock DH, Lim R, Nadkarni R, Huynh VT, Lim D, Chew WL, Zhong FL, Stroud DA, Schafer S, Tergaonkar V, St John AL, Rackham OJL, Ho L. Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity. Nat Commun. 2021 Apr 9;12(1):2130.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

April 9, 2021

Volume

12

Issue

1

Start / End Page

2130

Location

England

Related Subject Headings

  • Up-Regulation
  • Reactive Oxygen Species
  • Primary Cell Culture
  • Nuclear Proteins
  • Neoplasm Proteins
  • Mitochondria
  • MicroRNAs
  • Membrane Potential, Mitochondrial
  • Inflammation
  • Humans