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A new SOFA score calculation to improve the predictive performance for mortality in sepsis-associated disseminated intravascular coagulopathy patients.

Publication ,  Journal Article
Arakawa, M; Levy, JH; Fujimori, K; Kondo, K; Iba, T
Published in: J Crit Care
August 2021

PURPOSE: The change in the sequential organ failure assessment (SOFA) score from the entry day, a delta-SOFA (SOFAΔ), has been proposed as a better indicator for predicting mortality, and potentially as an endpoint in clinical trials. However, there are some concerns that the value of the absolute SOFA score has not been considered. The purpose of the study is to examine whether the addition of an absolute SOFA score can increase the predictive performance of SOFAΔ. MATERIALS AND METHODS: Data obtained from 297 patients with sepsis-associated disseminated intravascular coagulopathy (DIC) in multiinstitutional post-marketing surveys were analyzed retrospectively. The SOFAComb (SOFAΔ score + absolute SOFA score) and SOFAΔ were calculated, and the performance of each indicator was analyzed in terms of predictive ability for 28-day mortality. RESULTS: The area under the receiver operating curve (AUC) for the mortality of SOFAComb on day 2, 4, 7 were significantly greater compared to those of SOFAΔ (P <0.001, =0.002, <0.001, respectively). In addition, the accuracy [(True positive + True negative) / total number at the best cutoff points] of SOFAComb was better than that of SOFAΔ. CONCLUSIONS: SOFAComb is simple to calculate and provides better predictive performance compared to SOFAΔ for predicting mortality.

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Published In

J Crit Care

DOI

EISSN

1557-8615

Publication Date

August 2021

Volume

64

Start / End Page

108 / 113

Location

United States

Related Subject Headings

  • Sepsis
  • Retrospective Studies
  • ROC Curve
  • Prognosis
  • Organ Dysfunction Scores
  • Humans
  • Emergency & Critical Care Medicine
  • 4205 Nursing
  • 4201 Allied health and rehabilitation science
  • 3202 Clinical sciences
 

Citation

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Arakawa, M., Levy, J. H., Fujimori, K., Kondo, K., & Iba, T. (2021). A new SOFA score calculation to improve the predictive performance for mortality in sepsis-associated disseminated intravascular coagulopathy patients. J Crit Care, 64, 108–113. https://doi.org/10.1016/j.jcrc.2021.03.008
Arakawa, Makoto, Jerrold H. Levy, Kenji Fujimori, Kenta Kondo, and Toshiaki Iba. “A new SOFA score calculation to improve the predictive performance for mortality in sepsis-associated disseminated intravascular coagulopathy patients.J Crit Care 64 (August 2021): 108–13. https://doi.org/10.1016/j.jcrc.2021.03.008.
Arakawa, Makoto, et al. “A new SOFA score calculation to improve the predictive performance for mortality in sepsis-associated disseminated intravascular coagulopathy patients.J Crit Care, vol. 64, Aug. 2021, pp. 108–13. Pubmed, doi:10.1016/j.jcrc.2021.03.008.
Journal cover image

Published In

J Crit Care

DOI

EISSN

1557-8615

Publication Date

August 2021

Volume

64

Start / End Page

108 / 113

Location

United States

Related Subject Headings

  • Sepsis
  • Retrospective Studies
  • ROC Curve
  • Prognosis
  • Organ Dysfunction Scores
  • Humans
  • Emergency & Critical Care Medicine
  • 4205 Nursing
  • 4201 Allied health and rehabilitation science
  • 3202 Clinical sciences