Skip to main content

Return to Work Among Young Adult Survivors of Allogeneic Hematopoietic Cell Transplantation in the United States.

Publication ,  Journal Article
Bhatt, NS; Brazauskas, R; Salit, RB; Syrjala, K; Bo-Subait, S; Tecca, H; Badawy, SM; Baker, KS; Beitinjaneh, A; Bejanyan, N; Byrne, M; Dias, A ...
Published in: Transplant Cell Ther
August 2021

Young adult (YA) survivors of allogeneic hematopoietic cell transplantation (HCT) are at risk for late psychosocial challenges, including the inability to return to work post-HCT. Work-related outcomes in this population remain understudied, however. We conducted this study to assess the post-HCT work status of survivors of allogeneic HCT who underwent HCT as YAs and to analyze the patient-, disease-, and HCT-related factors associated with their work status at 1 year post-HCT. Using Center for International Blood and Marrow Transplant Research data, we evaluated the post-HCT work status (full-time, part-time work, unemployed, or medical disability) of 1365 YA HCT survivors who underwent HCT between 2008 and 2015. Percentages of work status categories were reported at 4 time points: 6 months, 1 year, 2 years, and 3 years post-HCT. Percentages of post-HCT work status categories at the 1-year time point were also described in relation to survivors' pre-HCT work status categories. Factors associated with 1-year post-HCT work status (full-time or part-time work) were examined using logistic regression. From 6 months to 3 years post-HCT, the percentage of survivors working full-time increased from 18.3% to 50.7% and the percentage working part-time increased from 6.9% to 10.5%. Of patients in full-time work pre-HCT, 50% were unemployed or on medical disability at 1 year post-HCT. Female sex (odds ratio [OR], 0.55; 95% confidence interval [CI], 0.40 to 0.77), HCT Comorbidity Index score ≥3 (OR, 0.57; 95% CI, 0.39 to 0.82), pre-HCT unemployment (OR, 0.37; 95% CI, 0.24 to 0.56), medical disability (OR, 0.44; 95% CI, 0.28 to 0.70), development of grade III-IV acute graft-versus-host disease (OR, 0.52; 95% CI, 0.34 to 0.80), and relapse within 1 year post-HCT (OR, 0.34; 95% CI, 0.21 to 0.56) were associated with a lower likelihood of employment at 1 year post-HCT. Compared with myeloablative conditioning (MAC) with total body irradiation (TBI), MAC without TBI (OR, 1.71; 95% CI, 1.16 to 2.53) was associated with a greater likelihood of employment at 1 year post-HCT. Graduate school-level education (OR, 2.47; 95% CI, 1.49 to 4.10) was also associated with a greater likelihood of employment at 1 year post-HCT. Although the work status among YA HCT survivors continued to improve over time, a substantial subset became or remained unemployed or on medical disability. These findings underscore the need for effective interventions to support return to work in this population.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Transplant Cell Ther

DOI

EISSN

2666-6367

Publication Date

August 2021

Volume

27

Issue

8

Start / End Page

679.e1 / 679.e8

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Transplantation, Homologous
  • Survivors
  • Return to Work
  • Neoplasm Recurrence, Local
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bhatt, N. S., Brazauskas, R., Salit, R. B., Syrjala, K., Bo-Subait, S., Tecca, H., … Shaw, B. (2021). Return to Work Among Young Adult Survivors of Allogeneic Hematopoietic Cell Transplantation in the United States. Transplant Cell Ther, 27(8), 679.e1-679.e8. https://doi.org/10.1016/j.jtct.2021.04.013
Bhatt, Neel S., Ruta Brazauskas, Rachel B. Salit, Karen Syrjala, Stephanie Bo-Subait, Heather Tecca, Sherif M. Badawy, et al. “Return to Work Among Young Adult Survivors of Allogeneic Hematopoietic Cell Transplantation in the United States.Transplant Cell Ther 27, no. 8 (August 2021): 679.e1-679.e8. https://doi.org/10.1016/j.jtct.2021.04.013.
Bhatt NS, Brazauskas R, Salit RB, Syrjala K, Bo-Subait S, Tecca H, et al. Return to Work Among Young Adult Survivors of Allogeneic Hematopoietic Cell Transplantation in the United States. Transplant Cell Ther. 2021 Aug;27(8):679.e1-679.e8.
Bhatt, Neel S., et al. “Return to Work Among Young Adult Survivors of Allogeneic Hematopoietic Cell Transplantation in the United States.Transplant Cell Ther, vol. 27, no. 8, Aug. 2021, pp. 679.e1-679.e8. Pubmed, doi:10.1016/j.jtct.2021.04.013.
Bhatt NS, Brazauskas R, Salit RB, Syrjala K, Bo-Subait S, Tecca H, Badawy SM, Baker KS, Beitinjaneh A, Bejanyan N, Byrne M, Dias A, Farhadfar N, Freytes CO, Ganguly S, Hashmi S, Hayashi RJ, Hong S, Inamoto Y, Jamani K, Kasow KA, Khera N, Krem MM, Lazarus HM, Lee CJ, Lee S, Majhail NS, Malone AK, Marks DI, Mau L-W, Mayo SJ, Muffly LS, Nathan S, Nishihori T, Page KM, Preussler J, Rangarajan HG, Rotz SJ, Salooja N, Savani BN, Schears R, Schechter-Finkelstein T, Schiller G, Shah AJ, Sharma A, Wang T, Wirk B, Battiwalla M, Schoemans H, Hamilton B, Buchbinder D, Phelan R, Shaw B. Return to Work Among Young Adult Survivors of Allogeneic Hematopoietic Cell Transplantation in the United States. Transplant Cell Ther. 2021 Aug;27(8):679.e1-679.e8.

Published In

Transplant Cell Ther

DOI

EISSN

2666-6367

Publication Date

August 2021

Volume

27

Issue

8

Start / End Page

679.e1 / 679.e8

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Transplantation, Homologous
  • Survivors
  • Return to Work
  • Neoplasm Recurrence, Local
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Female