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Abstract 2393: Kidneys of VHL patients reveal the origin of renal clear cell carcinoma

Publication ,  Conference
Mubarak, M; Sommaruga, S; Voigt, D; Xu, X; Kim, S; Song, A; Vortmeyer, AO
Published in: Cancer Research
July 15, 2016

VHL disease is a classic tumor suppressor gene syndrome characterized by development of specific types of tumors in selective organs with nervous system and kidney being most consistently affected. Detailed studies on human spinal cord and cerebellum have previously revealed earliest stages of CNS tumorigenesis and the morphologic sequence resulting in development of frank tumors.To elucidate earliest stages of renal clear cell carcinoma, we performed a similar approach in kidney tissues of four VHL patients and three sporadic control cases. From all cases, blocks of interest were procured, followed by serial sectioning and 3dimensional reconstruction of potential precursor lesions. The results reveal an abundance of foci with aberrant mesonephric clear cell proliferations that initially develop along the tubular lining, but have the potential to aggregate within individual tubules. This stage is followed by microscopic invasive clear cell aggregations which represent tumor precursor structures.This study presents evidence for a consistent morphologic sequence for renal clear cell carcinogenesis. Molecular analysis of early steps within this sequence will allow for identification of earliest genetic and proteomic changes in the future. Therapeutic targeting of earliest changes may allow to develop preventive strategies for renal cancer development for VHL patients, potentially also for the non-VHL population.Citation Format: Mayyan Mubarak, Samuel Sommaruga, David Voigt, Xiacao Xu, Steve Kim, Ailin Song, Alexander O. Vortmeyer. Kidneys of VHL patients reveal the origin of renal clear cell carcinoma. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2393.

Duke Scholars

Published In

Cancer Research

DOI

EISSN

1538-7445

ISSN

0008-5472

Publication Date

July 15, 2016

Volume

76

Issue

14_Supplement

Start / End Page

2393 / 2393

Publisher

American Association for Cancer Research (AACR)

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
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ICMJE
MLA
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Mubarak, M., Sommaruga, S., Voigt, D., Xu, X., Kim, S., Song, A., & Vortmeyer, A. O. (2016). Abstract 2393: Kidneys of VHL patients reveal the origin of renal clear cell carcinoma. In Cancer Research (Vol. 76, pp. 2393–2393). American Association for Cancer Research (AACR). https://doi.org/10.1158/1538-7445.am2016-2393
Mubarak, Mayyan, Samuel Sommaruga, David Voigt, Xiacao Xu, Steve Kim, Ailin Song, and Alexander O. Vortmeyer. “Abstract 2393: Kidneys of VHL patients reveal the origin of renal clear cell carcinoma.” In Cancer Research, 76:2393–2393. American Association for Cancer Research (AACR), 2016. https://doi.org/10.1158/1538-7445.am2016-2393.
Mubarak M, Sommaruga S, Voigt D, Xu X, Kim S, Song A, et al. Abstract 2393: Kidneys of VHL patients reveal the origin of renal clear cell carcinoma. In: Cancer Research. American Association for Cancer Research (AACR); 2016. p. 2393–2393.
Mubarak, Mayyan, et al. “Abstract 2393: Kidneys of VHL patients reveal the origin of renal clear cell carcinoma.” Cancer Research, vol. 76, no. 14_Supplement, American Association for Cancer Research (AACR), 2016, pp. 2393–2393. Crossref, doi:10.1158/1538-7445.am2016-2393.
Mubarak M, Sommaruga S, Voigt D, Xu X, Kim S, Song A, Vortmeyer AO. Abstract 2393: Kidneys of VHL patients reveal the origin of renal clear cell carcinoma. Cancer Research. American Association for Cancer Research (AACR); 2016. p. 2393–2393.

Published In

Cancer Research

DOI

EISSN

1538-7445

ISSN

0008-5472

Publication Date

July 15, 2016

Volume

76

Issue

14_Supplement

Start / End Page

2393 / 2393

Publisher

American Association for Cancer Research (AACR)

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis