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Cell adhesion molecules regulating astrocyte-neuron interactions.

Publication ,  Journal Article
Tan, CX; Eroglu, C
Published in: Current opinion in neurobiology
August 2021

A tripartite synapse comprises a neuronal presynaptic axon and a postsynaptic dendrite, which are closely ensheathed by a perisynaptic astrocyte process. Through their structural and functional association with thousands of neuronal synapses, astrocytes regulate synapse formation and function. Recent work revealed a diverse range of cell adhesion-based mechanisms that mediate astrocyte-synapse interactions at tripartite synapses. Here, we will review some of these findings unveiling a highly dynamic bidirectional signaling between astrocytes and synapses, which orchestrates astrocyte morphological maturation and synapse development. Moreover, we will discuss the roles of these newly discovered molecular pathways in brain physiology and function both in health and disease.

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Published In

Current opinion in neurobiology

DOI

EISSN

1873-6882

ISSN

0959-4388

Publication Date

August 2021

Volume

69

Start / End Page

170 / 177

Related Subject Headings

  • Synapses
  • Neurons
  • Neurogenesis
  • Cell Adhesion Molecules
  • Astrocytes
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
 

Citation

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MLA
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Tan, C. X., & Eroglu, C. (2021). Cell adhesion molecules regulating astrocyte-neuron interactions. Current Opinion in Neurobiology, 69, 170–177. https://doi.org/10.1016/j.conb.2021.03.015
Tan, Christabel X., and Cagla Eroglu. “Cell adhesion molecules regulating astrocyte-neuron interactions.Current Opinion in Neurobiology 69 (August 2021): 170–77. https://doi.org/10.1016/j.conb.2021.03.015.
Tan CX, Eroglu C. Cell adhesion molecules regulating astrocyte-neuron interactions. Current opinion in neurobiology. 2021 Aug;69:170–7.
Tan, Christabel X., and Cagla Eroglu. “Cell adhesion molecules regulating astrocyte-neuron interactions.Current Opinion in Neurobiology, vol. 69, Aug. 2021, pp. 170–77. Epmc, doi:10.1016/j.conb.2021.03.015.
Tan CX, Eroglu C. Cell adhesion molecules regulating astrocyte-neuron interactions. Current opinion in neurobiology. 2021 Aug;69:170–177.
Journal cover image

Published In

Current opinion in neurobiology

DOI

EISSN

1873-6882

ISSN

0959-4388

Publication Date

August 2021

Volume

69

Start / End Page

170 / 177

Related Subject Headings

  • Synapses
  • Neurons
  • Neurogenesis
  • Cell Adhesion Molecules
  • Astrocytes
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences