Genetically Informed Prostate Cancer Screening.
Publication
, Journal Article
Arcot, R; Morgan, TM; Polascik, TJ
Published in: Urol Clin North Am
August 2021
Prostate cancer represents a significant health care burden in the United States due to its incidence, treatment-related morbidity, and cancer-specific mortality. The burden begins with prostate-specific antigen screening, which has been subject to controversy due to concerns of overdiagnosis and overtreatment. Advancements in molecular oncology have provided evidence for the inherited predisposition to prostate cancer, which could improve individualized, risk-adapted approaches to screening and mitigate the harms of routine screening. This review presents the current evidence for the genetic basis of prostate cancer and novel genetically informed, risk-adapted screening strategies for prostate cancer.
Duke Scholars
Published In
Urol Clin North Am
DOI
EISSN
1558-318X
Publication Date
August 2021
Volume
48
Issue
3
Start / End Page
373 / 386
Location
United States
Related Subject Headings
- Urology & Nephrology
- Prostatic Neoplasms
- Prostate-Specific Antigen
- Polymorphism, Single Nucleotide
- Mass Screening
- Male
- Magnetic Resonance Imaging
- Humans
- Germ-Line Mutation
- Genetic Predisposition to Disease
Citation
APA
Chicago
ICMJE
MLA
NLM
Arcot, R., Morgan, T. M., & Polascik, T. J. (2021). Genetically Informed Prostate Cancer Screening. Urol Clin North Am, 48(3), 373–386. https://doi.org/10.1016/j.ucl.2021.04.001
Published In
Urol Clin North Am
DOI
EISSN
1558-318X
Publication Date
August 2021
Volume
48
Issue
3
Start / End Page
373 / 386
Location
United States
Related Subject Headings
- Urology & Nephrology
- Prostatic Neoplasms
- Prostate-Specific Antigen
- Polymorphism, Single Nucleotide
- Mass Screening
- Male
- Magnetic Resonance Imaging
- Humans
- Germ-Line Mutation
- Genetic Predisposition to Disease