Skip to main content
Journal cover image

Permissive and protective roles for neutrophils in leishmaniasis

Publication ,  Journal Article
Carlsen, ED; Liang, Y; Shelite, TR; Walker, DH; Melby, PC; Soong, L
Published in: Clinical and Experimental Immunology
October 13, 2015

Leishmania parasites are the causative agents of leishmaniasis, a neglected tropical disease that causes substantial morbidity and considerable mortality in many developing areas of the world. Recent estimates suggest that roughly 10 million people suffer from cutaneous leishmaniasis (CL), and approximately 76 000 are afflicted with visceral leishmaniasis (VL), which is universally fatal without treatment. Efforts to develop therapeutics and vaccines have been greatly hampered by an incomplete understanding of the parasite's biology and a lack of clear protective correlates that must be met in order to achieve immunity. Although parasites grow and divide preferentially in macrophages, a number of other cell types interact with and internalize Leishmania parasites, including monocytes, dendritic cells and neutrophils. Neutrophils appear to be especially important shortly after parasites are introduced into the skin, and may serve a dual protective and permissive role during the establishment of infection. Curiously, neutrophil recruitment to the site of infection appears to continue into the chronic phase of disease, which may persist for many years. The immunological impact of these cells during chronic leishmaniasis is unclear at this time. In this review we discuss the ways in which neutrophils have been observed to prevent and promote the establishment of infection, examine the role of anti-neutrophil antibodies in mouse models of leishmaniasis and consider recent findings that neutrophils may play a previously unrecognized role in influencing chronic parasite persistence.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Clinical and Experimental Immunology

DOI

EISSN

1365-2249

ISSN

0009-9104

Publication Date

October 13, 2015

Volume

182

Issue

2

Start / End Page

109 / 118

Publisher

Oxford University Press (OUP)

Related Subject Headings

  • Immunology
  • 1107 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Carlsen, E. D., Liang, Y., Shelite, T. R., Walker, D. H., Melby, P. C., & Soong, L. (2015). Permissive and protective roles for neutrophils in leishmaniasis. Clinical and Experimental Immunology, 182(2), 109–118. https://doi.org/10.1111/cei.12674
Carlsen, E. D., Y. Liang, T. R. Shelite, D. H. Walker, P. C. Melby, and L. Soong. “Permissive and protective roles for neutrophils in leishmaniasis.” Clinical and Experimental Immunology 182, no. 2 (October 13, 2015): 109–18. https://doi.org/10.1111/cei.12674.
Carlsen ED, Liang Y, Shelite TR, Walker DH, Melby PC, Soong L. Permissive and protective roles for neutrophils in leishmaniasis. Clinical and Experimental Immunology. 2015 Oct 13;182(2):109–18.
Carlsen, E. D., et al. “Permissive and protective roles for neutrophils in leishmaniasis.” Clinical and Experimental Immunology, vol. 182, no. 2, Oxford University Press (OUP), Oct. 2015, pp. 109–18. Crossref, doi:10.1111/cei.12674.
Carlsen ED, Liang Y, Shelite TR, Walker DH, Melby PC, Soong L. Permissive and protective roles for neutrophils in leishmaniasis. Clinical and Experimental Immunology. Oxford University Press (OUP); 2015 Oct 13;182(2):109–118.
Journal cover image

Published In

Clinical and Experimental Immunology

DOI

EISSN

1365-2249

ISSN

0009-9104

Publication Date

October 13, 2015

Volume

182

Issue

2

Start / End Page

109 / 118

Publisher

Oxford University Press (OUP)

Related Subject Headings

  • Immunology
  • 1107 Immunology