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Novel light-driven functional AgNPs induce cancer death at extra low concentrations.

Publication ,  Journal Article
Bunyatova, U; Hammouda, MB; Zhang, J
Published in: Sci Rep
June 24, 2021

The current study is aimed at preparing light-driven novel functional AgNPs- bio-hydrogel and evaluating anticancer potency against human melanoma cells. With an average size of 16-18 nm, the hydrogel nano-silver particle composite (AgNPs@C_MA_O) was synthesized using a soft white LED approach and analyzed by UV-Vis, DLS, FTIR, X-ray, SEM-EDX and TEM techniques. The anticancer activity of the obtained novel functionalized AgNPs@C_MA_O was tested in-vitro in the A375 melanoma cell line. Dose-response analysis showed that AgNPs at 0.01 mg/mL and 0.005 mg/mL doses reduced the viability of A375 cells by 50% at 24 and 48-h time-points, respectively. A375 cells treated with AgNPs@C_MA_O for 24 h at IC50 displayed abnormal morphology such as detachment edges and feet, shrinkage, membrane damage, and the loss of contact with adjacent cells. Our work is the first study showing that non-ionizing radiation mediated biofunctionalized AgNPs have an anti-tumoral effect at such a low concentration of 0.01 mg/mL. Our approach of using harmless wLED increased synergy between soft biopolymer compounds and AgNPs, and enhanced anticancer efficiency of the AgNPs@C_MA_O biohydrogel. Ultimately, the AgNPs accessed through the use of the wLED approach in colloidal syntheses can open new applications and combinatorial advanced cancer treatments and diagnostics.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

June 24, 2021

Volume

11

Issue

1

Start / End Page

13258

Location

England

Related Subject Headings

  • Microscopy, Electron, Scanning
  • Metal Nanoparticles
  • Melanoma
  • Light
  • Inhibitory Concentration 50
  • Hydrogels
  • Humans
  • Dose-Response Relationship, Drug
  • Cell Survival
  • Cell Line, Tumor
 

Citation

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ICMJE
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Bunyatova, U., Hammouda, M. B., & Zhang, J. (2021). Novel light-driven functional AgNPs induce cancer death at extra low concentrations. Sci Rep, 11(1), 13258. https://doi.org/10.1038/s41598-021-92689-9
Bunyatova, Ulviye, Manel Ben Hammouda, and Jennifer Zhang. “Novel light-driven functional AgNPs induce cancer death at extra low concentrations.Sci Rep 11, no. 1 (June 24, 2021): 13258. https://doi.org/10.1038/s41598-021-92689-9.
Bunyatova U, Hammouda MB, Zhang J. Novel light-driven functional AgNPs induce cancer death at extra low concentrations. Sci Rep. 2021 Jun 24;11(1):13258.
Bunyatova, Ulviye, et al. “Novel light-driven functional AgNPs induce cancer death at extra low concentrations.Sci Rep, vol. 11, no. 1, June 2021, p. 13258. Pubmed, doi:10.1038/s41598-021-92689-9.
Bunyatova U, Hammouda MB, Zhang J. Novel light-driven functional AgNPs induce cancer death at extra low concentrations. Sci Rep. 2021 Jun 24;11(1):13258.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

June 24, 2021

Volume

11

Issue

1

Start / End Page

13258

Location

England

Related Subject Headings

  • Microscopy, Electron, Scanning
  • Metal Nanoparticles
  • Melanoma
  • Light
  • Inhibitory Concentration 50
  • Hydrogels
  • Humans
  • Dose-Response Relationship, Drug
  • Cell Survival
  • Cell Line, Tumor